US 2001/0041802 A1Published application

Glucocorticoid receptor antagonists for treatment of diabetes

AssigneeAbbott Laboratories

InventorsPhilip R. Kym, Benjamin C. Lane, John K. Pratt, Tom Von Geldern, Martin Winn, Jehrod Brenneman, Jyoti R. Patel, David L. Arendsen, Irini Akritopoulou-Zanze, Kimba L. Ashworth, Kresna Hartandi

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Abstract

1 are useful for treating type II diabetes, obesity, hyperglycemia, inadequate glucose clearance, hyperinsulinemia, hypertriglyceridemia, and high-circulating glucocorticoid levels, preparations of the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Claims46

Dependent claims

or a pharmaceutically acceptable salt or prodrug thereof, wherein
R1 is selected from the group consisting of
(1) alkanoyl, cyano, halo, hydroxy;
(2) alkyl, alkenyl, alkynyl, alkoxy, alkanoyloxy;
wherein each group defining (2) can be optionally substituted with 1-4 substituents independently selected from alkoxy, alkoxycarbonyl, amino, carboxamido, cyano, halo, hydroxy, oxo, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, and unsubstituted or substituted heterocyclyl;
wherein the substituted aryl, substituted heteroaryl, and the substituted heterocyclyl groups are optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, perfluoroalkyl, and perfluoroalkoxy;
(3) cycloalkyl, aryl, heteroaryl, heterocyclyl;
wherein each group defining (3) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, carboxamido, carboxamidoalkyl, carboxy, carboxy, alkyl, cyano, cyanoalkyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, oxo, perfluoroalkyl, and perfluoroalkoxy;
(4) CO2R12, OR12, SR12, S(O)R12, and SO2R12;
wherein R12 is selected from the group consisting of
alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl;
wherein each group can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkoxyalkoxy, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy;
R2 is selected from hydrogen and R1;
or
R1 and R2 together are —X1—Y1—Z1—, wherein X1 is selected from a covelent bond, O and CH2;
Y1 is selected from C(O), alkylene, and alkenylene;
and Z1 is selected from CH2, CH2O, CH2NR13, NR13, and O;
wherein R13 is selected from
(1) hydrogen;
(2) alkyl;
wherein the alkyl can be optionally substituted with 1-4 substituents independently selected from alkenyl, alkoxy, cycloalkyl, aryl, halo;
and
(3) aryl;
R3, R4, R7, R8, and R9 are independently selected from hydrogen and R1;
L is selected from a covalent bond and alkylene;
R5 is selected from;
(1) alkanoyl, alkoxy, alkenyloxy, alkynyloxy, alkoxycarbonyl, cyano;
(2) aryl, arylalkyl, heteroaryl, and heterocyclyl;
wherein each group defining (2) can be optionally substituted with 1-5 substituents independently selected from alkanoylamino, alkanoylaryloxy, alkyl, alkylsulfonamido, alkenyl, alkenyloxy, alkynyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxyalkynyl, alkoxyaryl, alkoxycarbonyl, alkoxycarbonylalkyl, alkoxycarbonylalkenyloxy, amino, aminoalkyl, aminoaryl, aryl, arylalkyl, arylalkenyl, arylalkynyl, aryloxy, arylsulfonamido, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, carboxyaryl, cyano, cyanoalkyl, heteroaryl, (heteroaryl)heteroarylsulfonamido, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, hydroxyalkynyl, halo, haloalkyl, haloalkylsulfonamido, nitro, oxo, perfluoroalkyl, perfluoroalkoxy and trialkylsilylalkyl;
(3) alkyl, alkenyl, alkynyl, cycloalkyl;
wherein each group defining (3) can be optionally substituted with 1-4 substituents independently selected from alkoxy, alkenyloxy, alkoxycarbonyl, amino, aryl, carboxamido, carboxy, cyano, halo, hydroxy, and oxo;
R6 is selected from hydrogen and alkyl;
or
—L—R5 and R6 together are selected from
16
wherein d is 1-4 and A is selected from CH2, O, S, SO2, and NR13 and
17
wherein the carbon—carbon double bond of (2) can be in the E or Z configuration and R26 is selected from;
(1) alkyl;
wherein the alkyl can be optionally substituted with 1-4 substituents independently selected from alkenyl, alkynyl, alkoxy, alkoxycarbonyl, amino, aryl, carboxamido, carboxy, cyano, heteroaryl, heterocyclyl, hydroxy, and halo;
(2) aryl, heteroaryl, heterocyclyl, cycloalkyl, and cycloalkenyl;
wherein each group defining (2) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy;
R10 and R11 are independently selected from;
(1) hydrogen;
(2) alkyl;
wherein the alkyl can be optionally substituted with 1-4 substituents independently selected from (a) alkenyl, (b) alkynyl, (c) alkoxy, (d) aryl, (e) cycloalkyl, (f) heteroaryl, (g) heterocyclyl, (h) alkoxycarbonyl, (i) carboxy, and () halo;
wherein (a)-(c) can be optionally substituted with 1-4 substituents independently selected from aryl, alkoxy, cycloalkyl, heteroaryl, heterocyclyl, alkoxycarbonyl, carboxy, and halo;
and
wherein (d)-(g) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl;
alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy;
(3) aryl, cycloalkyl, heteroaryl, heterocyclyl;
wherein each group defining (3) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy;
(4) —SO2R35 and —C(O)R36;
wherein R35 and R36 are independently selected from
(a) alkoxy, amino;
(b) alkyl, alkenyl;
wherein each group defining (b) can be optionally substituted with 1-4 substituents independently selected from (i) alkenyl, (ii) alkynyl, (iii) alkoxy, (iv) aryl, (v) cycloalkyl, (vi) heteroaryl, (vii) heterocyclyl, (viii) alkoxycarbonyl, (ix) carboxy, and (x) halo;
wherein (i)-(iii) can be optionally substituted with 1-4 substituents independently selected from aryl, alkoxy, cycloalkyl, heteroaryl, heterocyclyl, alkoxycarbonyl, carboxy, and halo;
and
wherein (iv)-(vii) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy;
(c) aryl, cycloalkyl, heteroaryl, heterocyclyl;
wherein each group defining (c) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxy, alkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy.

59 more elements

A compound selected from the group consisting of

(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(31-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methylthio-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methylthio-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methylthio-6-(31-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methylthio-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methylthio-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methylthio-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methylthio-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethylthio-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethylthio-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethylthio-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethylthio-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethylthio-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethylthio-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethylthio-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethylthio-6-allyl-6H-dibenzo (b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethylthio-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethylthio-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethylthio-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethylthio-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethylthio-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-trifluoromethylthio-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methanesulfinyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methanesulfinyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methanesulfinyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methanesulfinyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methanesulfinyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methanesulfinyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(bed)pyran-8-yl)methanesulfonamide,
(1-methanesulfinyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methanesulfinyl-6-allyl -6H-dibenzo (b,d)pyran-8-yl)methanesulfonamide,
(1-ethanesulfinyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethanesulfinyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethanesulfinyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethanesulfinyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethanesulfinyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethanesulfinyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methanesulfonyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methanesulfonyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methanesulfonyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methanesulfonyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methanesulfonyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methanesulfonyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methanesulfonyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethanesulfonyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethanesulfonyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethanesulfonyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethanesulfonyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethanesulfonyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethanesulfonyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethanesulfonyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-bromo-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-bromo-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-bromo-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-bromo-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-bromo-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-bromo-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-bromo-6-(3-dimethoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-dimethylamino-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-dimethylamino-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-dimethylamino-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-dimethylamino-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-dimethylamino-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-dimethylamino-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-dimethylamino-6-(-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-diethylamino-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-diethylamino-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-diethylamino-6-(3-chlorophenyl)-6H-dibenzo(bud)pyran-8-yl)methanesulfonamide,
(1-diethylamino-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-diethylamino-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-diethylamino-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-diethylamino-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(N-methyl-N-ethylamino)-6-allyl-6H-dibenzo(b,d)pyran-8-yl )methanesulfonamide,
(1-(N-methyl-N-ethylamino)-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(N-methyl-N-ethylamino)-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(N-methyl-N-ethylamino)-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(N-methyl-N-ethylamino)-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(N-methyl-N-ethylamino)-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(N-methyl-N-ethylamino)-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(2-thienyl)-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(2-thienyl)-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(2-thinyl)-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(2-thienyl)-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(2-thienyl)-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(2-thienyl)-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(2-thienyl)-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(2-furanyl)-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(2-furanyl)-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(2-furanyl)-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(2-furanyl)-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(2-furanyl)-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(2-furanyl)-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(2-furanyl)-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethynyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethynyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethnyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethynyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethnyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethynyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethynyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-propyn-1-yl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-propyn-1-yl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-propyn-1-yl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-propyn-1-yl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-propyn-1-yl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-propyn-1-yl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-propyn-1-yl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-vinyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-vinyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-vinyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-vinyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-vinyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-vinyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-vinyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(propyn-2-yl)oxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(propyn-2-yl)oxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(propyn-2-yl)oxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(propyn-2-yl)oxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(propyn-2-yl)oxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(propyn-2-yl)oxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-(propyn-2-yl)oxy-6-(-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-cyano-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-cyano-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-cyano-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-cyano-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-cyano-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-cyano-6-(3,4-dimethoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-hydroxymethyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-hydroxymethyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-hydroxymethyl-6-(3-chlorophenyl)-6H-dibenzo (b,d)pyran-8-yl)methanesulfonamide,
(1-hydroxymethyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-hydroxymethyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-hydroxymethyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-hydroxymethyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-formyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-formyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-formyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-formyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-formyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-formyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-formyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-formaldoximino-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-formaldoximino-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-formaldoximino-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-formaldoximino-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-formaldoximino-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-formaldoximino-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-formaldoximino-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxymethyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxymethyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxymethyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxymethyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxymethyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxymethyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxymethyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-chloro-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-chloro-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-chloro-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-chloro-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-chloro-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-chloro-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-chloro-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-ethyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-1-ethyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-hydroxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-hydroxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-hydroxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-hydroxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-hydroxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-hydroxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-hydroxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-chloro-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-chloro-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-chloro-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-chloro-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-chloro-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-chloro-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-chloro-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-bromo-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-bromo-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-bromo-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-bromo-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-bromo-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-bromo-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-bromo-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-fluoro-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-fluoro-6-phenyl-6H-dibenzo(bud)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-fluoro-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-fluoro-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-fluoro-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-fluoro-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-fluoro-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-methyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-methyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-methyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-methyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-methyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-methyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-methyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-allyloxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-allyloxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-allyloxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-allyloxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-allyloxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-allyloxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-allyloxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-(2-allyloxy)ethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-(2-allyloxy)ethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-(2-allyloxy)ethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-(2-allyloxy)ethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-(2-allyloxy)ethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-(2-allyloxy)ethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-(2-allyloxy)ethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-(2-(2-methoxyethoxy)ethoxy)-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-(2-(2-methoxyethoxy)ethoxy)-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-(2-(2-methoxyethoxy)ethoxy)-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-(2-(2-methoxyethoxy)ethoxy)-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-(2-(2-methoxyethoxy)ethoxy)-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-(2-(2-methoxyethoxy)ethoxy)-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-2-(2-(2-methoxyethoxy)ethoxy)-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-hydroxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-hydroxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-hydroxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-hydroxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-hydroxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-hydroxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-hydroxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-chloro-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-chloro-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-chloro-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-chloro-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-chloro-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-chloro-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-chloro-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-bromo-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-bromo-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-bromo-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-bromo-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-bromo-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-bromo-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-bromo-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-fluoro-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-fluoro-6-phenyl-6H-dibenzo(bud)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-fluoro-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-fluoro-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-fluoro-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-fluoro-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-fluoro-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-methyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-methyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-methyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-methyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-methyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-methyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-methyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-allyloxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-allyloxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-allyloxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-allyloxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-allyloxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-allyloxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-allyloxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-(2-allyloxy)ethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-(2-allyloxy)ethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-(2-allyloxy)ethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-(2-allyloxy)ethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-(2-allyloxy)ethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-(2-allyloxy)ethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-(2-allyloxy)ethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-(2-(2-methoxyethoxy)ethoxy)-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-(2-(2-methoxyethoxy)ethoxy)-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-(2-(2-methoxyethoxy)ethoxy)-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-(2-(2-methoxyethoxy)ethoxy)-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-(2-(2-methoxyethoxy)ethoxy)-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-(2-(2-methoxyethoxy)ethoxy)-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-2-(2-(2-methoxyethoxy)ethoxy)-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-bromo-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-bromo-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-bromo-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-bromo-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-bromo-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-bromo-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-bromo-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-chloro-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-chloro-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-chloro-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-chloro-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-chloro-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-chloro-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-chloro-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-fluoro-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-fluoro-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-fluoro-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-fluoro-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-fluoro-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-fluoro-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-fluoro-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-methyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-methyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-methyl-6- ethynyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-methyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-methyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-methyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-methyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-bromo-6-allyl-6H-dibenzo(b,d)pyran-9-yl)methanesulfonamide,
(1-difluoromethoxy-3-bromo-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-bromo-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-bromo-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-bromo-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-bromo-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-bromo-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-chloro-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-chloro-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-chloro-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-chloro-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-chloro-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-chloro-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-chloro-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-fluoro-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-fluoro-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-fluoro-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-fluoro-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-fluoro-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-fluoro-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-fluoro-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-methyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-methyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-methyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-methyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-methyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-methyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-methyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-bromo-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-bromo-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-bromo-6-(3-chlorophenyl)-6H-dibenzo(bud)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-bromo-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-bromo-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-bromo-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-bromo-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-chloro-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-chloro-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-chloro-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-chloro-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-chloro-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-chloro-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-chloro-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-fluoro-6-allyl-6H-dibenzo(b,d)pyran-9-yl)methanesulfonamide,
(1-methoxy-3-fluoro-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-fluoro-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-fluoro-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-fluoro-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-fluoro-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-fluoro-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-methyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-methyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-methyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-methyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-methyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-3-methyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-bromo-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-bromo-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-bromo-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-bromo-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-bromo-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-bromo-6-(3,4-dimethoxy)phenyl-6H-dibenzo(bud)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-bromo-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-chloro-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-chloro-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-chloro-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-chloro-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-chloro-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-chloro-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-chloro-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-fluoro-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-fluoro-6-phenyl-6H1-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-fluoro-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-fluoro-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-fluoro-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-fluoro-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-fluoro-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-methyl-6-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-methyl-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-methyl-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-methyl-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-methyl-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-methyl-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-3-methyl-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-cyclohexyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-propyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-chlorobutyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(6-cyanohexyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-methoxy-2-buten-1-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-hydroxy-2-buten-1-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(but-3-en-1-yloxy)-2-buten-1-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(3-methoxypropoxy)-2-buten-1-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-allyloxybenzyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(2-carboxyethyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-carboxypropyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-carboxybutyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-carboxypentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(2-carbomethoxyethyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-carbomethoxypropyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-carbomethoxybutyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-carbomethoxypentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(2-carboethoxyethyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-carboethoxypropyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-carboethoxybutyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-carboethoxypentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(2,2-dimethyl-2-carboxyethyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3,3-dimethyl-3-carboxypropyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4,4-dimethyl-4-carboxybutyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5,5-dimethyl-5-carboxypentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(2,2-dimethyl-2-carbomethoxyethyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3,3-dimethyl-3-carbomethoxypropyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4,4-dimethyl-4-carbomethoxybutyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5,5-dimethyl-5-carbomethoxypentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(2,2-dimethyl-2-carboethoxyethyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3,3-dimethyl-3-carboethoxypropyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4,4-dimethyl-4-carboethoxybutyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5,5-dimethyl-5-carboethoxypentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-carboethoxypentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(6-hydroxyhexyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(6-oxohexyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(6-oxyhexyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(8-methoxyoctyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-(N-(2-methoxyethyl)aminocarbonyl)pentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-(N-methyl-N-(2-methoxyethyl)aminocarbonyl)pentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(2-carboxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(3-carboxypropyl)phenyl)-6H-dibenzo (b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(4-carboxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(5-carboxypentyl)phenyl)-6H-dibenzo(bed)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(2-carbomethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(3-carbomethoxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(4-carbomethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(5-carbomethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(2-carboethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(3-carboethoxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(4-carboethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(5-carboethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(2,2-dimethyl-2-carboxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(3 , 3-dimethyl-3-carboxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(4,4-dimethyl-4-carboxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(5,5-dimethyl-5-carboxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(2,2-dimethyl-2-carbomethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(3,3-dimethyl-3-carbomethoxypropylphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(4,4-dimethyl-4-carbomethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(5,5-dimethyl-5-carbomethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(2,2-dimethyl-2-carboethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(3 , 3-dimethyl-3-carboethoxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(4,4-dimethyl-4-carboethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(5,5-dimethyl-5-carboethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(2-carboxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(3-carboxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(4-carboxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(5-carboxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(2-carbomethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(3-carbomethoxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(4-carbomethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(5-carbomethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(2-carboethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(3-carboethoxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(4-carboethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(5-carboethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(2,2-dimethyl-2-carboxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(3,3-dimethyl-3-carboxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(4,4-dimethyl-4-carboxybutyl)phenyl)-6H-dibenzo(bud)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(5,5-dimethyl-5-carboxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(2,2-dimethyl-2-carbomethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(3,3-dimethyl-3-carbomethoxypropylphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(4,4-dimethyl-4-carbomethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(5,5-dimethyl-5-carbomethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(2,2-dimethyl-2-carboethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(3 , 3-dimethyl-3-carboethoxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(4,4-dimethyl-4-carboethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(5,5-dimethyl-5-carboethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(N-methyl-N-(N,N-dimethylaminocarbonyl)methylamino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(N-methyl-N-(N,N-diethylaminocarbonyl)methylamino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(2-(N-methyl-N-(N,N-dimethylaminocarbonyl)ethyl)amino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(2-(N-methyl-N-(N,N-diethylaminocarbonyl)ethyl)amino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(3-(N-methyl-N-(N,N-dimethylcarbonyl)propyl)amino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(3-(N-methyl-N-(N,N-diethylaminocarbonyl)propyl)amino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(N-methyl-N-acetyl)aminophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(N-methyl-N-propionyl)aminophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(N-methyl-N-methanesulfonyl)aminophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(N-methyl-N-ethanesulfonyl)aminophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-hydroxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-trifluoromethylphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-methylphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-bromophenyl) -6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-bromophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6- (3-cyanophenyl) -6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-cyanophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-carbomethoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-carbomethoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-carboethoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-carboethoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-ethoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-ethoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-allyloxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-allyloxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-allylphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-allylphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(thien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(-chlorothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-(3-methoxypropen-1-yl)thien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-(3-methoxypropyl)thien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(furan-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(pyridin-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(pyridin-3-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(pyridin-4-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-bromopyridin-3-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-(N-methyl-N-(2-methoxyethyl)amino)pyridin-3-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-(3-methoxypropen-1-yl)pyridin-3-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(N-methylamino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(N-allyl-N-methylamino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(4-(N-propyl-N-methylamino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(N-methanesulfonylamino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(N-methyl-N-propanesulfonylamino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(4-methoxybutoxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(4-methoxybut-2-en-1-yloxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(4-hydroxybut-2-en-1-yloxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(3-carboethoxyprop-2-en-1-yloxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(2-(2-methoxyethoxy)ethoxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-((N-methyl-N-(2-methoxyethyl)amino)carbonyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(methylthiomethoxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(2-hydroxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(2-methoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(2-(but-3-en-1-yloxy)ethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(2-(N,N-dimethylaminocarbonyloxy)ethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(N,N-dimethylaminocarbonyloxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-(3-bromoprop-2-en-1-yloxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-fluoro-5-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-fluoro-5-hydroxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-fluoro-5-allyloxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-fluoro-5-(2-methoxyethoxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-fluoro-5-(2-(2-methoxyethoxy)ethoxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-fluoro-5-(2-allyloxyethoxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-cyclohexyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-propyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-chlorobutyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(6-cyanohexyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-methoxy-2-buten-1-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-hydroxy-2-buten-1-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(but-3-en-1-yloxy)-2-buten-1-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(3-methoxypropoxy)-2-buten-1-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-allyloxybenzyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(2-carboxyethyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-carboxypropyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-carboxybutyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-carboxypentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(2-carbomethoxyethyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-carbomethoxypropyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-carbomethoxybutyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-carbomethoxypentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(2-carboethoxyethyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-carboethoxypropyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-carboethoxybutyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-carboethoxypentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(2,2-dimethyl-2-carboxyethyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3,3-dimethyl-3-carboxypropyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4,4-dimethyl-4-carboxybutyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5,5-dimethyl-5-carboxypentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(2,2-dimethyl-2-carbomethoxyethyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3,3-dimethyl-3-carbomethoxypropyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4,4-dimethyl-4-carbomethoxybutyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5,5-dimethyl-5-carbomethoxypentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(2,2-dimethyl-2-carboethoxyethyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3,3-dimethyl-3-carboethoxypropyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4,4-dimethyl-4-carboethoxybutyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5,5-dimethyl-5-carboethoxypentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-carboethoxypentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(6-hydroxyhexyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(6-oxohexyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(6-methoxyhexyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(8-methoxyoctyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-(N-(2-methoxyethyl)aminocarbonyl)pentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-(N-methyl-N-(2-methoxyethyl)aminocarbonyl)pentyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(2-carboxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(3-carboxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(4-carboxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(5-carboxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(2-carbomethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(3-carbomethoxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(4-carbomethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(5-carbomethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(2-carboethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(3-carboethoxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(4-carboethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(5-carboethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(2,2-dimethyl-2-carboxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(3,3-dimethyl-3-carboxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(4,4-dimethyl-4-carboxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(5,5-dimethyl-5-carboxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(2,2-dimethyl-2-carbomethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(3,3-dimethyl-3-carbomethoxypropylphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(4,4-dimethyl-4-carbomethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(5,5-dimethyl-5-carbomethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(2,2-dimethyl-2-carboethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(3,3-dimethyl-3-carboethoxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(4,4-dimethyl-4-carboethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(5,5-dimethyl-5-carboethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(2-carboxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(3-carboxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(4-carboxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(5-carboxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(2-carbomethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(3-carbomethoxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(4-carbomethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(5-carbomethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(2-carboethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(3-carboethoxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(4-carboethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(5-carboethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(2,2-dimethyl-2-carboxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(3,3-dimethyl-3-carboxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(4,4-dimethyl-4-carboxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(5,5-dimethyl-5-carboxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(2,2-dimethyl-2-carbomethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(3,3-dimethyl-3-carbomethoxypropylphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(4,4-dimethyl-4-carbomethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(5,5-dimethyl-5-carbomethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(2,2-dimethyl-2-carboethoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(3,3-dimethyl-3-carboethoxypropyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(4,4-dimethyl-4-carboethoxybutyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(5,5-dimethyl-5-carboethoxypentyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(N-methyl-N-(N,N-dimethylaminocarbonyl)methylamino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(N-methyl-N-(N,N-diethylaminocarbonyl)methylamino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(2-(N-methyl-N-(N,N-dimethylaminocarbonyl)ethyl)amino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(2-(N-methyl-N-(N,N-diethylaminocarbonyl)ethyl)amino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(3-(N-methyl-N-(N,N-dimethylaminocarbonyl)propyl)amino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(3-(N-methyl-N-(N,N-diethylaminocarbonyl)propyl)amino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(N-methyl-N-acetyl)aminophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(N-methyl-N-propionyl)aminophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(N-methyl-N-methanesulfonyl)aminophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(N-methyl-N-ethanesulfonyl)aminophenyl)-6H-dibenzo(b1d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-hydroxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-trifluoromethylphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-methylphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-bromophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-bromophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-cyanophenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-cyanophenyl)-6H-dibenzo(b,d)pyran-9-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-carbomethoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-carbomethoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-carboethoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-carboethoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3- ethoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-ethoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-allyloxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-allyloxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-allylphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-allylphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(thien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-chlorothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-(3-methoxypropen-1-yl)thien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-(3-methoxypropyl)thien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(furan-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(pyridin-2-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(pyridin-3-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(pyridin-4-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-bromopyridin-3-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-(N-methyl-N-(2-methoxyethyl)amino)pyridin-3-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-(3-methoxypropen-1-yl)pyridin-3-yl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(N-methylamino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(N-allyl-N-methylamino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(4-(N-propyl-N-methylamino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(N-methanesulfonylamino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(N-methyl-N-propanesulfonylamino)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(4-methoxybutoxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(4-methoxybut-2-en-1-yloxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(4-hydroxybut-2-en-1-yloxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(3-carboethoxyprop-2-en-1-yloxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(2-(2-methoxyethoxy)ethoxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-((N-methyl-N-(2-methoxyethyl)amino)carbonyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(methylthiomethoxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(2-hydroxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(2-methoxyethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(2-(but-3-en-1-yloxy)ethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(2-(N,N-dimethylaminocarbonyloxy)ethyl)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(N,N-dimethylaminocarbonyloxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-(3-bromoprop-2-en-1-yloxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-fluoro-5-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-fluoro-5-hydroxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-fluoro-5-allyloxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-fluoro-5-(2-methoxyethoxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-fluoro-5-(2-(2-methoxyethoxy)ethoxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-fluoro-5-(2-allyloxyethoxy)phenyl)-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-allyl-7-bromo-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-allyl-7-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-phenyl-7-bromo-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-phenyl-7-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-chlorophenyl)-7-bromo-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-chlorophenyl)-7-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-fluorophenyl)-7-bromo-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-fluorophenyl)-7-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-methoxyphenyl)-7-bromo-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-methoxyphenyl)-7-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-7-bromo-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-7-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-bromothien-2-yl)-7-bromo-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-bromothien-2-yl)-7-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-allyl-7-bromo-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-allyl-7-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-phenyl-7-bromo-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-phenyl-7-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-7-bromo-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-7-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-7-bromo-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-7-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-7-bromo-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-7-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-7-bromo-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-7-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-7-bromo-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-7-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-allyl-8-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-phenyl-8-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-chlorophenyl)-8-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-fluorophenyl)-8-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-methoxyphenyl)-8-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-8-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(5-bromothien-2-yl)-8-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-allyl-8-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-phenyl-8-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-8-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-8-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-8-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-8-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-8-methyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-allyl-9-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-phenyl-9-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-chlorophenyl)-9-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-fluorophenyl)-9-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3-methoxyphenyl)-9-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-9-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-(-bromothien-2-yl)-9-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-allyl-9-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-phenyl-9-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-9-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-9-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-9-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-9-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-9-allyl-6H-dibenzo(b,d)pyran-8-yl)methanesulfonamide,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)acetamide,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)propionamide,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)benzamide,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylsulfonylurea,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-diethylsulfonylurea,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N-methyl-N-ethylsulfonylurea,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)aniline,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N-ethylaniline,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N-methylaniline,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)ethanesulfonamide,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide,
(1-methoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-thiophene-2-sulfonamide,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)acetamide,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)propionamide,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)benzamide,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylsulfonylurea,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-diethylsulfonylurea,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-methyl-N-ethylsulfonylurea,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)aniline,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-ethylaniline,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-methylaniline,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)ethanesulfonamide,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide,
(1-methoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-thiophene-2-sulfonamide,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)acetamide,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)propionamide,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)benzamide,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylsulfonylurea,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-diethylsulfonylurea,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-methyl-N-ethylsulfonylurea,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)aniline,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-ethylaniline,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-methylaniline,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)ethanesulfonamide,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide,
(1-methoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-thiophene-2-sulfonamide,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)acetamide,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)propionamide,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)benzamide,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)(2methoxy)acetamide,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylsulfonylurea,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-diethylsulfonylurea,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-methyl-N-ethylsulfonylurea,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)aniline,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-ethylaniline,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-methylaniline,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)ethanesulfonamide,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide,
(1-methoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-thiophene-2-sulfonamide,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)acetamide,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d pyran-8-yl)propionamide,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)benzamide,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylsulfonylurea,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-diethylsulfonylurea,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-methyl-N-ethylsulfonylurea,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)aniline,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-ethylaniline,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-methylaniline,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)ethanesulfonamide,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide,
(1-methoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-thiophene-2-sulfonamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)acetamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)propionamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)benzamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylsulfonylurea,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-diethylsulfonylurea,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-methyl-N-ethylsulfonylurea,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)aniline,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-ethylaniline,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-methylaniline,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)ethanesulfonamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide,
(1-methoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-thiophene-2-sulfonamide,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)acetamide,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)propionamide,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)benzamide,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylsulfonylurea,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-diethylsulfonylurea,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N-methyl-N-ethylsulfonylurea,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)aniline,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N-ethylaniline,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N-methylaniline,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)ethanesulfonamide,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide,
(1-methoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-thiophene-2-sulfonamide,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)acetamide,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)propionamide,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)benzamide,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylsulfonylurea,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-diethylsulfonylurea,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N-methyl-N-ethylsulfonylurea,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)aniline,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N-ethylaniline,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N-methylaniline,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)ethanesulfonamide,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide,
(1-difluoromethoxy-6-allyl-6H-dibenzo(b,d)pyran-8-yl)-thiophene-2-sulfonamide,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)acetamide,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)propionamide,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)benzamide,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylsulfonylurea,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-diethylsulfonylurea,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-methyl-N-ethylsulfonylurea,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)aniline,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-ethylaniline,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-methylaniline,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)ethanesulfonamide,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide,
(1-difluoromethoxy-6-phenyl-6H-dibenzo(b,d)pyran-8-yl)-thiophene-2-sulfonamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)acetamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)propionamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)benzamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylsulfonylurea,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-diethylsulfonylurea,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-methyl-N-ethylsulfonylurea,
(1-difluoromethoxy-6-(3-chlorophenyl)-6 H-dibenzo(b,d)pyran-8-yl)aniline,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-ethylaniline,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-methylaniline,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)ethanesulfonamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide,
(1-difluoromethoxy-6-(3-chlorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-thiophene-2-sulfonamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(bed)pyran-8-yl)acetamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)propionamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)benzamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylsulfonylurea,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-diethylsulfonylurea,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-methyl-N-ethylsulfonylurea,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)aniline,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-ethylaniline,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-methylaniline,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)ethanesulfonamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide,
(1-difluoromethoxy-6-(3-fluorophenyl)-6H-dibenzo(b,d)pyran-8-yl)-thiophene-2-sulfonamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)acetamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)propionamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)benzamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylsulfonylurea,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-diethylsulfonylurea,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-methyl-N-ethylsulfonylurea,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)aniline,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-ethylaniline,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-methylaniline,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)ethanesulfonamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide,
(1-difluoromethoxy-6-(3-methoxyphenyl)-6H-dibenzo(b,d)pyran-8-yl)-thiophene-2-sulfonamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)acetamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)propionamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)benzamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylsulfonylurea,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N,N-diethylsulfonylurea,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-methyl-N-ethylsulfonylurea,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)aniline,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-ethylaniline,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-methylaniline,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)ethanesulfonamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide,
(1-difluoromethoxy-6-(3,4-dimethoxy)phenyl-6H-dibenzo(b,d)pyran-8-yl)-thiophene-2-sulfonamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)acetamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)propionamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methyl)propionamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)benzamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)cyclopropanamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-(2-methoxy)acetamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)trifluoroacetamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylurea,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylthiourea,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-dimethylsulfonylurea,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N,N-diethylsulfonylurea,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N-methyl-N-ethylsulfonylurea,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)aniline,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N-ethylaniline,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N-methylaniline,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N-(cyclopropylmethyl)aniline,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-N-benzylaniline,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)benzenesulfonamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)ethanesulfonamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)isopropanesulfonamide,
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-(2-fluorobenzene)sulfonamide, and
(1-difluoromethoxy-6-(5-bromothien-2-yl)-6H-dibenzo(b,d)pyran-8-yl)-thiophene-2-sulfonamide.

1,091 more elements

Dependencies are inferred from the claim text.

Facts

Application: 09/795,998Filed 28 Feb 2001
Priority: 1 Sep 1999
Published: 15 Nov 2001
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07D 407/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
A61P 7/12
Drugs for disorders of the blood or the extracellular fluid: antidiuretics, e.g. drugs for diabetes insipidus
C07D 311/80
Ring systems having three or more relevant rings: dibenzopyrans; Hydrogenated dibenzopyrans

Family

Application60/151,839Us provisional application · filed 1 Sep 1999
Application09/654,322Continuation in part · filed 1 Sep 2000
Application09/795,998Continuation in part · filed 28 Feb 2001
US 6,329,534 B1Related patent
US 6,593,480 B2Related patent
US 2001/0041802 A1This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

or a pharmaceutically acceptable salt or prodrug thereof, wherein
R1 is selected from the group consisting of
(1) alkanoyl, cyano, halo, hydroxy;
(2) alkyl, alkenyl, alkynyl, alkoxy, alkanoyloxy;
wherein each group defining (2) can be optionally substituted with 1-4 substituents independently selected from alkoxy, alkoxycarbonyl, amino, carboxamido, cyano, halo, hydroxy, oxo, unsubstituted or substituted aryl, unsubstituted or substituted heteroaryl, and unsubstituted or substituted heterocyclyl;
wherein the substituted aryl, substituted heteroaryl, and the substituted heterocyclyl groups are optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, perfluoroalkyl, and perfluoroalkoxy;
(3) cycloalkyl, aryl, heteroaryl, heterocyclyl;
wherein each group defining (3) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, carboxamido, carboxamidoalkyl, carboxy, carboxy, alkyl, cyano, cyanoalkyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, oxo, perfluoroalkyl, and perfluoroalkoxy;
(4) CO2R12, OR12, SR12, S(O)R12, and SO2R12;
wherein R12 is selected from the group consisting of
alkyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl;
wherein each group can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkoxyalkoxy, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy;
R2 is selected from hydrogen and R1;
or
R1 and R2 together are —X1—Y1—Z1—, wherein X1 is selected from a covelent bond, O and CH2;
Y1 is selected from C(O), alkylene, and alkenylene;
and Z1 is selected from CH2, CH2O, CH2NR13, NR13, and O;
wherein R13 is selected from
(1) hydrogen;
(2) alkyl;
wherein the alkyl can be optionally substituted with 1-4 substituents independently selected from alkenyl, alkoxy, cycloalkyl, aryl, halo;
and
(3) aryl;
R3, R4, R7, R8, and R9 are independently selected from hydrogen and R1;
L is selected from a covalent bond and alkylene;
R5 is selected from;
(1) alkanoyl, alkoxy, alkenyloxy, alkynyloxy, alkoxycarbonyl, cyano;
(2) aryl, arylalkyl, heteroaryl, and heterocyclyl;
wherein each group defining (2) can be optionally substituted with 1-5 substituents independently selected from alkanoylamino, alkanoylaryloxy, alkyl, alkylsulfonamido, alkenyl, alkenyloxy, alkynyl, alkoxy, alkoxyalkoxy, alkoxyalkyl, alkoxyalkynyl, alkoxyaryl, alkoxycarbonyl, alkoxycarbonylalkyl, alkoxycarbonylalkenyloxy, amino, aminoalkyl, aminoaryl, aryl, arylalkyl, arylalkenyl, arylalkynyl, aryloxy, arylsulfonamido, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, carboxyaryl, cyano, cyanoalkyl, heteroaryl, (heteroaryl)heteroarylsulfonamido, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, hydroxyalkynyl, halo, haloalkyl, haloalkylsulfonamido, nitro, oxo, perfluoroalkyl, perfluoroalkoxy and trialkylsilylalkyl;
(3) alkyl, alkenyl, alkynyl, cycloalkyl;
wherein each group defining (3) can be optionally substituted with 1-4 substituents independently selected from alkoxy, alkenyloxy, alkoxycarbonyl, amino, aryl, carboxamido, carboxy, cyano, halo, hydroxy, and oxo;
R6 is selected from hydrogen and alkyl;
or
—L—R5 and R6 together are selected from
16
wherein d is 1-4 and A is selected from CH2, O, S, SO2, and NR13 and
17
wherein the carbon—carbon double bond of (2) can be in the E or Z configuration and R26 is selected from;
(1) alkyl;
wherein the alkyl can be optionally substituted with 1-4 substituents independently selected from alkenyl, alkynyl, alkoxy, alkoxycarbonyl, amino, aryl, carboxamido, carboxy, cyano, heteroaryl, heterocyclyl, hydroxy, and halo;
(2) aryl, heteroaryl, heterocyclyl, cycloalkyl, and cycloalkenyl;
wherein each group defining (2) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy;
R10 and R11 are independently selected from;
(1) hydrogen;
(2) alkyl;
wherein the alkyl can be optionally substituted with 1-4 substituents independently selected from (a) alkenyl, (b) alkynyl, (c) alkoxy, (d) aryl, (e) cycloalkyl, (f) heteroaryl, (g) heterocyclyl, (h) alkoxycarbonyl, (i) carboxy, and () halo;
wherein (a)-(c) can be optionally substituted with 1-4 substituents independently selected from aryl, alkoxy, cycloalkyl, heteroaryl, heterocyclyl, alkoxycarbonyl, carboxy, and halo;
and
wherein (d)-(g) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl;
alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy;
(3) aryl, cycloalkyl, heteroaryl, heterocyclyl;
wherein each group defining (3) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy;
(4) —SO2R35 and —C(O)R36;
wherein R35 and R36 are independently selected from
(a) alkoxy, amino;
(b) alkyl, alkenyl;
wherein each group defining (b) can be optionally substituted with 1-4 substituents independently selected from (i) alkenyl, (ii) alkynyl, (iii) alkoxy, (iv) aryl, (v) cycloalkyl, (vi) heteroaryl, (vii) heterocyclyl, (viii) alkoxycarbonyl, (ix) carboxy, and (x) halo;
wherein (i)-(iii) can be optionally substituted with 1-4 substituents independently selected from aryl, alkoxy, cycloalkyl, heteroaryl, heterocyclyl, alkoxycarbonyl, carboxy, and halo;
and
wherein (iv)-(vii) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxyalkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy;
(c) aryl, cycloalkyl, heteroaryl, heterocyclyl;
wherein each group defining (c) can be optionally substituted with 1-5 substituents independently selected from alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, amino, aminoalkyl, aryl, carboxamido, carboxamidoalkyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, heteroaryl, heterocyclyl, hydroxy, hydroxyalkyl, hydroxy, alkoxy, halo, haloalkyl, nitro, perfluoroalkyl, and perfluoroalkoxy.

59 more elements

Facts

Application

09/795,998Filed 28 Feb 2001

Priority

1 Sep 1999

Published

15 Nov 2001

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07D 407/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
A61P 7/12
Drugs for disorders of the blood or the extracellular fluid: antidiuretics, e.g. drugs for diabetes insipidus
C07D 311/80
Ring systems having three or more relevant rings: dibenzopyrans; Hydrogenated dibenzopyrans

Family

Application60/151,839Us provisional application · filed 1 Sep 1999

Application09/654,322Continuation in part · filed 1 Sep 2000

Application09/795,998Continuation in part · filed 28 Feb 2001

US 6,329,534 B1Related patent

US 6,593,480 B2Related patent

US 2001/0041802 A1This patent

From the US filing history. Foreign family members aren’t listed.