Extraction of growth factors from tissue
OwnerRussell S. Donda, John F. Wironeninventors
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Abstract
Disclosed herein are novel methods of obtaining osteogenic and other growth factor compositions from alternative nonbone sources such as tissue or bone marrow, and methods of using the same. Also disclosed are implants infused with growth factors obtained from the methods disclosed herein.
Claims39
A method of obtaining growth factors from tissue comprising the steps of:
- (a) obtaining tissue;
- and
- (b) extracting one or more growth factors from said tissue.
A growth factor composition comprising a growth factor derived from tissue and a carrier.
An osteogenic growth factor composition comprising an osteogenic growth factor obtained from nonbone tissue;
- a carrier component;
- and one or more other osteogenic components.
An osteogenic growth factor extracted from muscle.
Platelet rich plasma obtained from an allogenic or xenogenic cadaveric donor tissue source.
A method of obtaining platelet rich plasma comprising the steps of:
- (a) procuring blood that has been removed from living or cadaveric donors, or both;
- and
- (b) separating platelet rich plasma from other blood components.
A growth factor composition comprising one or more growth factors that have been extracted from allogenic or xenogenic platelet rich plasma.
An article of manufacture comprising a container and a growth factor composition disposed within said container.
A method of repairing a wound, defect or other injury comprising contacting an implant with PRP obtained from allogenic or xenogenic sources, or both;
- and implanting said implant in a patient in need thereof.
A method of repairing a wound, defect or other injury comprising contacting an implant with one or more growth factors extracted from PRP obtained from allogenic or xenogenic sources, or both;
- and implanting said implant in a patient in need thereof.
A biomedical implant infused with one or more growth factors derived from cadaveric, nonbone tissue.
A biomedical implant comprised of a calcium phosphate composition, wherein said implant is infused with one or more growth factors derived from cadaveric tissue.
A growth factor composition comprising one or more growth factors derived from cadaveric tissue and a carrier;
- wherein said carrier comprises growth factors obtained from bone;
- carrier associated mineralized particles;
- morsellized skin or other tissue;
- Fibrin powder;
- Fibrin/plasminogen glue;
- bioactive glass;
- bioactive ceramic;
- Demineralized Bone Matrix (DBM)/glycerol;
- cortico cancellous chips (CCC);
- DBM/pleuronic F127;
- DBM/CCC/F127;
- human tissue associated with polyesters polyhydroxy compounds, polyvinyl compounds, polyamino compounds, or polycarbonate compounds;
- and combinations thereof.
A method of extracting growth factors from platelets comprising the steps of:
- obtaining a sample of platelets apheretically separated from donor blood;
- centrifuge platelets to separate platelets from plasma;
- and
- agitate platelets in an extraction buffer to lyse platelets.
Dependencies are inferred from the claim text.