Cytotoxic T lymphocyte epitopes of the major outer membrane protein of chlamydia trachomatis
AssigneeWisconsin Alumni Research Foundation
InventorsRobert I. DeMars, Seon-Kyeong Kim
Life of this patent
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Abstract
Disclosed herein are 9 amino acid-long peptides from the major outer membrane protein (MOMP) of Chlamydia trachomatis serovar E. These peptides activate CD8+ cytotoxic T-lymphocytes in human infections that are potentially important for resolution of infection and protection against disease. Thus, the peptides, as well as DNA coding for them, are intended for use in vaccination of humans. Also, they are useful in connection with diagnostic tests.
Claims11
A DNA nucleotide sequence capable of expressing a peptide of 9 to 10 amino acid residues that activates cytotoxic T-lymphocytes, the peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, and SEQ ID NO:
- 6, SEQ ID NO:
- 7, and SEQ ID NO:
- 8, wherein the peptide does not have more than 10 amino acid residues.
A vaccine against Chlamydia trachomatis comprising a peptide of 9 to 10 amino acid residues that activates cytotoxic T-lymphocytes, the peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, and SEQ ID NO:
- 6, SEQ ID NO:
- 7, and SEQ ID NO:
- 8, wherein the peptide does not have more than 10 amino acid residues.
Dependencies are inferred from the claim text.