Amino ceramide - like compounds and therapeutic methods of use
AssigneeThe Regents of the University of Michigan
InventorsJames A. Shayman, Norman S. Radin
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Abstract
Novel amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
Claims20
A method for inhibiting the growth of cancer cells in a mammal, comprising the step of administering to the mammal a therapeutically effective amount of a comprising a compound selected from the group consisting of D-t-3′,4′ethylenedi-oxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol, D-t-4′-hydroxy-1phenyl-2-almitoylamino-3-pyrrolidino-1-propanol, functional homologues, isomers, pharmaceutically acceptable salts , and mixtures thereof, wherein said cancer cells are sensitive to said compound.
A method for treating a patient having a drug resistant tumor, comprising the step of administering to the patient a therapeutically effective amount of a composition comprising a compound selected from the group consisting of D-t-3′,4′-ethylenedioxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol, D-t4-hydroxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol, functional homologues, isomers, pharmaceutically acceptable salts, and mixtures thereof, wherein the tumor is sensitive to said compound.
A method for reducing tumor angiogenesis in a patient, comprising the step of administering to the patient a therapeutically effective amount of a composition comprising a compound selected from the group consisting of D-t-3′,4′-ethylenedioxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol, D-t-4-hydroxy-1-phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol, functional homologues, isomers, pharmaceutically acceptable salts, and mixtures thereof, wherein said angiogenesis is sensitive to said compound.
A compound selected from the group consisting of the formula
- 5
- where R1 is 4-hydroxyphenyl or 3,4-ethylendioxy phenyl;
- R2 is an aliphatic chain having 10 to 18 carbons;
- and
- R3is pyrrolidino.
A method for inhibiting the growth of cancer cells in a mammal, comprising the step of administering to the mammal a therapeutically effective amount of a composition comprising the compound of claim 24, wherein said cancer cells are sensitive to said compound.
Dependencies are inferred from the claim text.