Use

A method for the treatment of a condition associated with reduced nicotine transmission, by administering to a patient in need of such treatment, a medically effective amount of a positive modulator of a nicotinic receptor agonist, said positive modulator having the capability to increase the efficacy of the said nicotinic receptor agonist.

A method for identifying a positive modulator of a nicotinic receptor agonist, said method comprising the steps (a) expressing a nicotinic receptor on the surface of a cell;

• (b) contacting the said nicotinic receptor with a compound known to be a nicotinic receptor agonist and a compound to be tested for positive modulating activity;
• (c) determining whether the compound to be tested exhibits a positive modulation on the effect of the said nicotinic receptor agonist.

A method for identifying a compound which is a nicotinic receptor agonist, said method comprising the steps (a) expressing a nicotinic receptor on the surface of a cell;

• (b) contacting the said nicotinic receptor with a compound to be tested for nicotinic receptor agonist activity, in the presence of a positive modulator of a nicotinic receptor agonist;
• and (c) determining whether the compound to be tested exhibits nicotinic receptor agonist activity.

Use of a positive modulator of a nicotinic receptor agonist in the manufacture of a medicament for treatment of or prophylaxis of a condition associated with reduced nicotine transmission.

Use of a positive modulator of a nicotinic receptor agonist together with a nicotinic receptor agonist in the manufacture of a medicament for treatment of a condition associated with reduced nicotine transmission.