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US 2001/0041730 A1Published application
Tetrahydronaphtalene derivatives and their use
AssigneesNovo Nordisk A/S, South Alabama Medical Science Foundation
InventorsMing Li, John Bondo Hansen, Tina Moller Tagmose
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Abstract
Tetrahydronaphatalene derivatives, and compositions comprising the compounds. The tetrahydronaphatalene derivates are useful in inhibiting a rise in intracellular calcium mediated by an influx through T-type calcium channels, and are thus useful for treatment of, for example, type 1 and type 2 diabetes and cardiovascular diseases associated with diabetes.
Claims18
A compound of formula (I):
- 4
- wherein R1 is H, C1-6-alkyl or phenyl which is optionally substituted with halogen, methoxy or C1-6-alkyl;
- and R2—C—R3 together forms a C3-6-cycloalkyl group;
- or a pharmaceutically acceptable salt thereof.
1 more element
A compound of formula (I):
- 5
- wherein R1 is h or C1-6-alkyl and R2—C—R3 together forms a C3-6-cycloalkyl group, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.