Compositions and methods for treating cancer
AssigneeThe Procter & Gamble Company
InventorJames Berger Camden
Life of this patent
Estimating the term…
Abstract
This invention is a pharmaceutical composition that inhibits the growth of cancers and tumors in mammals, particularly in human and warm blooded animals. The composition contains N-chlorophenylcarbamates and N-chlorophenylthiocarbamates along with a chemotherapeutic agent and optionally a potentiator. A composition for treating viral infections in animals or humans comprising a safe and effective amount of N-chlorophenylcarbamates and the N-chlorophenylthiocarbamates and a potentiator is also disclosed.
Claims26
A pharmaceutical composition for treating cancers or tumors comprising a safe and effective amount of a chemotherapeutic agent and a safe and effective amount of a N-chlorophenylcarbamates and N-chlorophenylthiocarbamates of the formula:
- 3
- wherein n is from 1 to 3;
- X is selected from the group consisting oxygen and sulfur and wherein R is selected from the group consisting of hydrogen, lower alkyl and lower alkenyl, cyclohexyl, phenyl and phenalkyl of up to 8 carbon atoms and pharmaceutically acceptable inorganic or organic acid salts of these compounds.
A method of treating cancer in warm blooded mammals comprising administering a safe and effective amount of a pharmaceutical composition comprising a chemotherapeutic agent and a N-chlorophenylcarbamates and N-chlorophenylthiocarbamates of the formula:
- 4
- wherein n is from 1 to 3, X is selected from the group consisting of oxygen and sulfur and R is selected from the group consisting of hydrogen, lower alkyl and lower alkenyl, cyclohexyl, phenalkyl of up to 8 carbon atoms, phenyl, and pharmaceutically acceptable organic or inorganic acid salts of these compounds.
A unit dosage composition effective for treating cancers and tumors comprising a safe and effective amount of a chemotherapeutic agent N-chlorophenylcarbamates and N-chlorophenylthiocarbamates of the formula:
- 5
- wherein X is selected from the group consisting of oxygen and sulfur, n is from 1 to 3 and R is selected from the group consisting of hydrogen, lower alkyl and lower alkenyl, cyclohexyl, phenalkyl of up to 8 carbon atoms, phenyl, and the pharmaceutically acceptable organic and inorganic acid salts thereof, and a safe and effective carrier.
A unit dosage composition for treating viral infections in animals or humans comprising a safe and effective amount of N-chlorophenylcarbamates and the N-chlorophenylthiocarbamates and a potentiator.
A method of treating viral infections comprising administering a safe and effective amount of a pharmaceutical composition comprising a potentiator and N-chlorophenylcarbamates and N-chlorophenylthiocarbamates of the formula:
- 6
- wherein n is from 1 to 3, X is selected from the group consisting of oxygen and sulfur and R is selected from the group consisting of hydrogen, lower alkyl and lower alkenyl, cyclohexyl, phenalkyl of up to 8 carbon atoms, phenyl, and pharmaceutically acceptable organic or inorganic acid salts of these compounds.
Dependencies are inferred from the claim text.