Glycosides and orthoester glycosides of glucocorticoids and uses thereof
OwnerMichael F. Holick, Halasya Ramanathaninventors
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Abstract
Serum levels of therapeutically useful glucocorticosteroids are substantially increased by oral administration of the corresponding glycoside or orthoester glycoside.
Claims20
A composition for the treatment of a condition treatable by the systemic administration of a glucocorticosteroid, comprising that glucocorticosteroid and a pharmaceutically acceptable carrier therefor, characterized in that the glucocorticosteroid is a derivative in the form of a glycoside or orthoester glycoside, or salt or ester of the derivative.
A glucocorticosteroid derivative in the form of a glycoside or orthoester glycoside, or salt or ester of thereof, wherein said glucocorticosteriod does not have a high first pass metabolism in the liver.
Dependencies are inferred from the claim text.