Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues
OwnerAnthony A. Fossainventor
Life of this patent
Estimating the term…
Abstract
This invention is directed to pharmaceutical compositions comprising corticotropin releasing factor antagonist and growth hormone or growth hormone secretagogues, prodrugs thereof, or pharmaceutically acceptable salts of said compounds or said prodrugs. The invention is also directed to methods of treating heart related diseases (including congestive heart failure) in mammals, and particularly in humans.
Claims35
A pharmaceutical composition comprising a corticotropin releasing factor antagonist and a growth hormone secretagogue or growth hormone.
A method for treating or preventing osteoporosis, frailty associated with aging or obesity, cardiovascular or heart related disease, for accelerating bone fracture repair, attenuating protein catabolic response after a major operation, reducing cachexia and protein loss due to chronic illness, accelerating wound healing, or accelerating the recovery of burn patients or of patients having undergone major surgery, said method comprising administering to a human or other animal an amount of a corticotropin releasing factor antagonist and an amount of a growth hormone secretagogue or growth hormone.
A kit comprising:
- a. an amount of a corticotropin releasing factor antagonist, in a first unit dosage form;
- b. an amount of a growth hormone secretagogue or growth hormone, in a second unit dosage form;
- and
- c. a container.
A kit, comprising
- a. a pharmaceutical composition, comprising an amount of a growth hormone or growth hormone secretagogue;
- b. a package containing the above composition;
- and
- c. a package insert that may be integral with said package;
- wherein it is stated on the package insert that the pharmaceutical composition is to be administered simultaneously or in a specifically timed manner with a pharmaceutical composition containing at least one corticotropin releasing factor antagonist.
A kit, comprising
- a. a pharmaceutical composition, comprising an amount of a corticotropin releasing factor antagonist;
- b. a package containing the above composition;
- and
- c. a package insert that may be integral with said package;
- wherein it is stated on the package insert that the pharmaceutical composition is to be administered simultaneously or in a specifically timed manner with a pharmaceutical composition containing at least one growth hormone or growth hormone secretagogue.
Dependencies are inferred from the claim text.