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US 2001/0041365 A1Published application
Methods for monitoring alcohol consumption
OwnerMichael Laposatainventor
Life of this patent
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Abstract
The invention relates to methods for differentiating chronic alcoholics from acute alcoholics (i.e., binge drinkers), using levels of ethyl oleate and ethyl palmitate. Also provided are methods for determining ethanol intake, including post-mortem determination of ante-mortem ethanol intake.
Claims95
A method for identifying a chronic alcoholic comprising
- determining a concentration of ethyl oleate (O) and a concentration of ethyl palmitate (P) in a sample from a subject, and
- determining a P/O ratio of the concentration of ethyl palmitate (P) to the concentration of ethyl oleate (O) in the sample,
- wherein a P/O ratio less than 0.9 is indicative of a chronic alcoholic.
A method for identifying a chronic alcoholic comprising
- determining a concentration of ethyl oleate (O) in a sample from a subject,
- wherein a concentration of ethyl oleate (O) greater than 100 pmol/mL is indicative of a chronic alcoholic.
A method for identifying a chronic alcoholic comprising
- determining a concentration of ethyl oleate (O) and a concentration of total FAEE (T) in a sample from a subject, and
- determining an O/T ratio of the concentration of ethyl oleate (O) to the concentration of total FAEE (T) in the sample,
- wherein an O/T ratio greater than 0.52 is indicative of a chronic alcoholic.
A method for determining ethanol intake comprising
- determining an amount of total FAEE in a liver sample from a subject
- determining an amount of total FAEE in an adipose tissue sample from the subject, and
- adding the amount of total FAEE in the liver sample to the amount of total FAEE in the adipose tissue sample to produce a combined total FAEE amount,
- wherein a combined total FAEE amount of greater than 2000 pmol/g is indicative of ethanol intake by the subject.
1 more element
A method for determining ethanol intake in a subject, comprising
- determining an amount of total FAEE in a liver sample from the subject
- determining an amount of total FAEE in an adipose tissue sample from the subject, and
- determining the ratio of the amount of total liver FAEE to the amount of total adipose FAEE,
- wherein a ratio of the amount of total liver FAEE to the amount of total adipose FAEE of at least 2 is indicative of ethanol intake by the subject.
1 more element
A method for determining ethanol intake in a subject, comprising
- determining an amount of ethyl arachidonate in a tissue selected from the group consisting of liver tissue and adipose tissue,
- wherein an amount of ethyl arachidonate of at least 200 pmol/gram in the tissue is indicative of ethanol intake.
A kit for determining an amount of FAEE in a sample comprising
- a collection tube,
- a control amount of isolated FAEE,
- an ice pack,
- a thermal container, and
- instructions for processing of the sample.
2 more elements
A method for identifying a binge drinker comprising
- determining a concentration of ethyl oleate (O) and a concentration of ethyl palmitate (P) in a sample from a subject, and
- determining a P/O ratio of the concentration of ethyl palmitate (P) to the concentration of ethyl oleate (O) in the sample,
- wherein a P/O ratio greater than 1.0 is indicative of a binge drinker.
A method for identifying a binge drinker comprising
- determining a concentration of ethyl oleate (O) in a sample from a subject,
- wherein a concentration of ethyl oleate less than 100 pmol/mL is indicative of a binge drinker.
A method for identifying a binge drinker comprising
- determining a concentration of ethyl oleate (O) and a concentration of total FAEE (T) in a sample from a subject, and
- determining an O/T ratio of the concentration of ethyl oleate (O) to the concentration of total FAEE (T) in the sample,
- wherein an O/T ratio less than 0.52 is indicative of a binge drinker.
A computer program product, comprising:
- a computer-readable medium;
- and
- computer-readable signals stored on the computer-readable medium that define instructions that, as a result of being executed by a computer, instruct the computer to perform a process of determining ethanol intake by a subject, the process comprising steps (or acts) of
- determining whether combined total amount of liver and adipose FAEE is at least 2000 pmol/gram;
- determining whether ratio of total liver FAEE to total adipose FAEE is at least two;
- determining whether amount of liver or adipose ethyl arachidonate is at least 200 pmol/g;
- wherein i) a combined total amount of liver and adipose FAEE of at least 2000 pmol/gram, or ii) a ratio of total liver FAEE to total adipose FAEE of at least two and an amount of total liver FAEE of at least 10,000 pmol/g, or iii) an amount of ethyl arachidonate level in liver or adipose of at least 200 pmol/g, are each indicative of ethanol intake by a subject.
4 more elements
A method of determining ethanol intake by a subject, comprising
- determining whether combined total amount of liver and adipose FAEE is at least 2000 pmol/gram;
- determining whether ratio of total liver FAEE to total adipose FAEE is at least two;
- determining whether amount of liver or adipose ethyl arachidonate is at least 200 pmol/g;
- wherein i) a combined total amount of liver and adipose FAEE of at least 2000 pmol/gram, or ii) a ratio of total liver FAEE to total adipose FAEE of at least two and an amount of total liver FAEE of at least 10,000 pmol/g, or iii) an amount of ethyl arachidonate level in liver or adipose of at least 200 pmol/g, are each indicative of ethanol intake by a subject,
- wherein the method is implemented on a computer.
2 more elements
Dependencies are inferred from the claim text.