Microarrays and their manufacture
AssigneeLarge Scale Proteomics Corporation
InventorsNorman G. Anderson, N. Leigh Anderson
Life of this patent
Estimating the term…
Abstract
The microarrays of the present invention are prepared by using a separate fiber for each compound being used in the microarray. The fibers are bundled and sectioned to form a thin microarray that is glued to a backing.
Claims50
A fiber bundle comprising a plurality of fibers attached to each other in a fixed position with respect to each other wherein the fibers have different molecules of interest immobilized in or on different fibers.
An array comprising a plurality of cells in a known location on the array, each cell containing a molecule of interest immobilized in or on at least a portion of a fiber, wherein different cells contain different fibers or portions of a fiber which contains a different molecule of interest immobilized therein or thereon, and wherein each molecule of interest is located in a known cell.
A microarray comprising a solid phase support and at least about 500 cells per square centimeter wherein each cell contains a molecule of interest which is not chemically bound to the solid phase support.
A microarray comprising a solid phase support and at least about 500 cells per square centimeter wherein each cell contains a molecule of interest which is a macromolecule, a microorganism, a plant or animal cell, an organelle or a fraction of a biological cell.
A microarray comprising a solid phase support and at least about 500 cells per square centimeter wherein each cell contains a molecule of interest which was synthesized prior to contacting the solid phase support.
A microarray comprising a solid phase support and at least about 500 different cells per square centimeter wherein each cell is formed by a solid material adhered to said solid phase support wherein each solid material contains a molecule of interest.
A multiwell plate containing at least about 500 wells per square centimeter.
A thin elongated fiber impregnated with a solid phase wherein the solid phase is bound to a molecule of interest.
An solid phase construct containing an immobilized molecule of interest comprising an embedding medium, a porous or hollow solid phase and a molecule of interest,
- wherein the molecule of interest is immobilized on inside surfaces of the porous or hollow solid phase,
- wherein the porous or hollow solid phase is embedded in the embedding medium, and
- wherein the inside surfaces are exposed to the surface of the construct by cleaving such that individual porous or hollow solid phases are cleaved in plural sections.
A microarray containing a plurality of different cells wherein each cell contains a solid phase support, a porous particle containing a molecule of interest immobilized on an inside surface of a porous particle and a medium for attaching said particle to said solid phase support in a particular cell.
An elongated fiber having a molecule of interest immobilized thereon or therein such that a detectable number of a single molecule of interest are present in each millimeter of fiber length.
Dependencies are inferred from the claim text.