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AssigneesMedtronic Vascular, Inc., The United States of America as represented by the Department of Health and Human Services
InventorsAnthony L. Fitzhugh, Peiwen Cheng, Joseph Saavedra, Robert Cafferata, Marc Hendriks, Larry K. Keefer, Eugene Tedeschi, Michel I.P.M. Verhoeven
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Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.
A method for preparing a nitric oxide-releasing metallic surface comprising:
A method for preparing a nitric oxide-releasing metallic surface comprising:
A method for preparing a nitric oxide-releasing metallic surface comprising:
Medical devices for delivering nitric oxide in therapeutic concentrations for sustained periods of time comprising:
Dependencies are inferred from the claim text.