Water soluble lipidated arabinogalactan
AssigneeThe University of Montana
InventorGeoffrey N. Richards
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Abstract
Arabinogalactan compositions are provided which are useful in a wide variety of different biomedical applications. In one embodiment, water soluble lipidated arabinogalactans are provided which include arabinogalactan with a limited proportion of lipophilic groups, such as long-chain hydrocarbon groups, covalently attached to free hydroxyl groups on the arabinogalactan. The lipidated arabinogalactans are water soluble and biocompatible and are useful for a wide variety of different biomedical applications. The lipidated arabinogalactans can be used, for example, to inhibit cell adhesion, and to inhibit infection or inflammation. The lipidated arabinogalactans further may be used as adjuvants, to inhibit metastasis, and in other therapeutic applications.
Claims22
A compound comprising arabinogalactan covalently attached to a lipophilic group, wherein the compound is water soluble.
A method for treating diseases in animals and humans caused by infectious organisms comprising administering an effective amount of a water soluble compound, comprising arabinogalactan covalently attached to a lipophilic group, to alleviate the disease.
A method for treating diseases in animals and humans caused by inflammation, the method comprising administering an effective amount of a water soluble compound, comprising arabinogalactan covalently attached to a lipophilic group, to alleviate the disease.
A method for inhibiting metastasis in animals or humans comprising administering an effective amount of a water soluble compound, comprising arabinogalactan covalently attached to a lipophilic group, to alleviate the disease.
An improvement in a method for producing an immune response in an animal or human to an antigen, the method comprising administering the antigen to the animal or human together with a compound comprising arabinogalactan covalently attached to a lipophilic group.
Dependencies are inferred from the claim text.