Inhibition of cell-cell binding by lipid assemblies
AssigneeThe Regents of the University of California
InventorsJon O. Nagy, Robert F. Bargatze
Life of this patent
Estimating the term…
Abstract
This invention relates generally to the field of therapeutic compounds designed to interfere between the binding of ligands and their receptors on cell surface. More specifically, it provides products and methods for inhibiting cell migration and activation using lipid assemblies with surface recognition elements that are specific for the receptors involved in cell migration and activation.
Claims42
Compositions comprising lipid assemblies, wherein said lipid assemblies comprise:
- a) a plurality of lipid monomers;
- b) one or more surface exposed oxyacid groups;
- and
- c) one or more surface exposed carbohydrates;
- wherein said lipid assemblies are capable of inhibiting the binding between a first cell having a receptor and a second cell having a ligand for said receptor.
Compositions comprising one or more polymerized lipid assemblies, wherein said polymerized lipid assemblies comprise:
- a) a plurality of lipid monomers;
- and
- b) one or more surface exposed oxyacid groups;
- wherein said polymerized lipid assemblies are capable of inhibiting the binding between a first cell having a receptor and a second cell having a ligand for said receptor.
A method for inhibiting the binding between a first cell having a receptor and a second cell having a ligand for said receptor, comprising:
- a) providing:
- i) a sample containing said first cell and said second cell;
- and
- ii) a polymerized lipid assembly comprising a plurality of lipid monomers and one or more surface exposed oxyacid groups;
- and
- b) exposing said polymerized lipid assembly to said first cell.
A method for inhibiting the binding between a first cell having a receptor and a second cell having a ligand for said receptor, comprising:
- a) providing:
- i) a sample containing said first cell and said second cell;
- and
- ii) a lipid assembly comprising a plurality of lipid monomers, one or more surface exposed oxyacid groups, and one or more surface exposed carbohydrates;
- and
- b) exposing said polymerized lipid assembly to said first cell.
Dependencies are inferred from the claim text.