C5a receptor
AssigneeHuman Genome Sciences, Inc.
InventorsYi Li, Craig A. Rosen
Life of this patent
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Abstract
A human C5a receptor polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists and agonists may be used therapeutically to inhibit or stimulate the C5a receptor. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.
Claims53
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide encoding the polypeptide comprising amino acid 1 to 355 as set forth in SEQ ID NO:2;
- (b) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a);
- and
- (c) a polynucleotide fragment of the polynucleotide of (a) or (b).
An isolated polynucleotide comprising a member selected from the group consisting of:
- (a) a polynucleotide encoding a mature polypeptide encoded by the DNA contained in ATCC Deposit No. 75821;
- (b) a polynucleotide encoding a polypeptide expressed by the DNA contained in ATCC Deposit No. 75821;
- (c) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a) or (b);
- and
- (d) a polynucleotide fragment of the polynucleotide of (a), (b) or (c).
A receptor polypeptide comprising a member selected from the group consisting of:
- (a) a polypeptide having the deduced amino acid sequence of SEQ ID NO:2 and fragments, analogs and derivatives thereof;
- and
- (b) a polypeptide encoded by the cDNA of ATCC Deposit No. 75821 and fragments, analogs and derivatives of said polypeptide.
An isolated polypeptide comprising:
- a polypeptide fragment of a human C5a receptor polypeptide, wherein said human C5a receptor polypeptide consists of amino acid residues 1 to 355 of SEQ ID NO:2, and further wherein said polypeptide fragment binds an antibody directed to the polypeptide of SEQ ID NO:2.
An isolated polypeptide comprising:
- at least 30 contiguous amino acid residues of a human C5a receptor polypeptide, wherein said human C5a receptor polypeptide consists of amino acid residues 1 to 355 of SEQ ID NO:2.
An isolated polypeptide comprising:
- a polypeptide fragment of a human C5a receptor polypeptide, wherein said human C5a receptor polypeptide is encoded by the human cDNA contained in ATCC Deposit No. 75821, and further wherein said polypeptide fragment catalyzes GTP to GDP.
An isolated polypeptide comprising:
- at least 30 contiguous amino acid residues of a human C5a receptor polypeptide, wherein said human C5a receptor polypeptide is encoded by the human cDNA contained in ATCC Deposit No. 75821.
Dependencies are inferred from the claim text.