Autoimmune inner ear disease diagnostic assay
OwnerTai-June Yooinventor
Life of this patent
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Abstract
Methods for diagnosing and monitoring autoimmune inner ear diseases such as Meniere's disease by combining a sample with one or more antigens and detecting the binding of antibodies in the sample to the antigen. The antigen is an inner ear collagen protein or peptide including type II collagen, type IX collagen, or type XI collagen. Binding is detected using an assay method such as an ELISA immunoassay. The assay may further include one or more additional inner ear antigens such as the signal transduction protein Raf-1, the myelin protein P0 and β-tubulin.
Claims20
A method for detecting an autoimmune inner ear disease antibody in a sample comprising combining the sample with an antigen and detecting the binding of the antigen to the antibody, wherein the antigen is an inner ear collagen molecule.
A kit for detecting an autoimmune inner ear disease antibody in a sample comprising an inner ear collagen molecule and an immunoassay reagent.
The kit of claim 13 wherein the inner ear collagen molecule is a collagen protein.
Dependencies are inferred from the claim text.