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US 2001/0036631 A1Published application
Evaluating and predicting clinical outcomes by gene expression analysis
AssigneeOxo Chemie AG
InventorsMichael McGrath, Stefan Meuer, Friedrich-Wilhelm Kuehne
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Abstract
Methods of determining clinical outcomes in patients suffering from a pathological condition or syndrome are provided. Levels of intracellular gene expression re measured from a clinical sample provided by the patient, and the levels are compared to reference levels. Deviations from reference levels are predictive of clinical outcomes, for example, disease progression or response to therapeutic intervention.
Claims25
A method of evaluating a clinical outcome for a patient suffering from a clinical condition or syndrome, comprising the steps of
- (a) providing a clinical specimen from said patient;
- (b) measuring the levels of intracellular expression of a preselected set of genes in cells in said clinical specimen;
- and
- (c) comparing said levels of expression against a set of reference expression levels, wherein a deviation of the level of expression of one or more of said preselected set of genes is indicative of clinical outcome for said patient.
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