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US 2001/0036626 A1Published application
Screening assay methods and systems using target pooling
OwnerJavier A. Farinas, H. Garrett Wadainventors
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Abstract
Methods, devices and systems for increasing the throughput of screening assays by pooling multiple target systems, which allow a library of different materials, e.g., test compounds, to be screened against the pooled targets to determine whether any of the materials affect one or more of the target systems. In preferred aspects, functioning of individual target systems is identified by differences in physical, chemical and/or optical properties particular to the target system in a target pool.
Claims43
A method of performing a screening assay, comprising:
- providing a first target mixture in a first reaction vessel, the first target mixture comprising at least first and second different target systems;
- introducing at least a first test agent into the target mixture;
- and
- determining an effect of the test agent on the first and second target systems.
1 more element
A system for performing high throughput screening assays, comprising:
- a reaction vessel having a first target mixture disposed therein, the first target mixture comprising at least first and second target systems, the first target mixture being different from the first target system;
- a test agent sampler for sampling a test agent and introducing the test agent into the reaction vessel;
- and
- a detector positioned in sensory communication with the first target mixture, the detector being configured to detect an effect of a test agent on the first and second target systems.
1 more element
Dependencies are inferred from the claim text.