Enhancement of antibody-mediated immune responses
AssigneeThe Rockefeller University
InventorJeffrey V. Ravetch
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Abstract
The present invention is related to enhancing the function of anti-tumor antibodies by regulating FcγRIIB-mediated activity. In particular, disrupting SHIP activation by FcγRIIB enhances cytotoxicity elicited by a therapeutic antibody in vivo in a human. The invention further provides an antibody, e.g., an anti-tumor antibody, with a variant Fc region that results in binding of the antibody to FcγRIIB with reduced affinity. A variety of transgenic mouse models demonstrate that the inhibiting FcγRIIB molecule is a potent regulator of cytotoxicity in vivo.
Claims21
A method for enhancing cytotoxicity elicited by a therapeutic antibody in vivo in a subject, which method comprises disrupting activation of SHIP by Fc-gamma-receptor IIB (FcγRIIB).
An antibody with a variant Fc region, which antibody binds FcγRIIB with reduced affinity.
Dependencies are inferred from the claim text.