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US 2001/0034451 A1Published application
Phenyl-substituted 1,4-dihydropyridines
AssigneeBayer Aktiengesellschaft
InventorsHeinrich Meier, Wolfgang Hartwig, Bodo Junge, Rudolf Schohe-Loop, Zhan Gao, Bernard Schmidt, Maarten de Jonge, Teunis Schuurman
Life of this patent
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Abstract
Novel phenyl-substituted 1,4-dihydropyridines, prepared by reacting halogenophenyl-aldehydes with β-ketoesters, if appropriate with isolation of the ylidene compounds and enamines. The substances can be employed as active compounds in medicaments, in particular in cerebrally active compositions.
Claims9
Phenyl-substituted 1,4-dihydropyridines of the general formula
- 82
- in which
- R1 and R3 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by straight-chain or branched alkoxy having up to 6 carbon atoms or hydroxyl, or represent cycloalkyl having 3 to 7 carbon atoms,
- and R2 represents the radical
- 83
- in which
- R4 and R5 are identical or different and represent halogen, cyano, ethinyl, trifluoromethoxy, methyl, methylthio, trifluoromethyl or straight-chain or branched alkoxy having up to 4 carbon atoms, or
- R4 or R5 represents hydrogen
- and their salts.
6 more elements
Dependencies are inferred from the claim text.