Viral treatment
AssigneeThe Protector & Gamble Company
InventorJames Berger Camden
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Abstract
A pharmaceutical composition that inhibits or slows the infection or reinfection of animals, particularly mammals, by HIV or other retroviruses is disclosed. The composition comprises from about 10 mg to about 6000 mg of a (5-aryl-1,2,4-thiadiazol)-3-yl thiourea derivative or (5-aryl-1,2,4-thiadiazol)-3-yl urea derivative of the formula: 1 wherein X is oxygen or sulfur, R is hydrogen or alkyl having from 1-3 carbons, n is 1-4, R1 is independently selected from the group consisting of hydrogen, alkyl having from 1 to 7 carbon atoms, chloro, bromo or fluoro, oxychloro, alkoxy having the formula —O(CH2)yCH3 wherein y is from 1 to 6, or a pharmaceutically acceptable acid addition salt or prodrug thereof. The preferred compound is (5-phenyl-1,2,4-thiadazol-3-yl) thiourea
Claims12
A method of preventing HIV and retroviral infections comprising administering to a patient in need thereof a therapeutically effective amount of (5-aryl-1,2,4-thiadiazol)-3-yl thiourea derivative or (5-aryl- 1,2,4-thiadizol)-3-yl urea derivative having the formula:
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- wherein X is oxygen or sulfur, R is hydrogen or alkyl having from 1-3 carbons, n is 1-4, R1 is independently selected from the group consisting of hydrogen, alkyl having from 1 to 7 carbon atoms, chloro, bromo or fluoro, oxychloro, alkoxy having the formula —O(CH2)yCH3 wherein y is from 1 to 6, or the pharmaceutically acceptable acid addition salt or prodrugs thereof for a period of time sufficient to build up immunity to the infection with the virus.
A method of treating viral infections comprising administering a therapeutically effective amount of (5-phenyl-1,2,4-thiadiazol)-3-yl thiourea having the formula:
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- wherein X is sulfur, R is hydrogen, n is 1-4, R1 is independently selected from the group consisting of hydrogen or alkyl having from 1 to 7 carbon atoms or the prodrugs or pharmaceutically acceptable addition salt thereof.
Dependencies are inferred from the claim text.