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US 2001/0034339 A1Published application
Topical suspension formulations containing ciprofloxacin and dexamethasone
AssigneeAlcon Universal Ltd.
InventorsOnkar N. Singh, Haresh G. Bhagat
Life of this patent
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Abstract
Suspension formulations containing dexamethasone and ciprofloxacin are disclosed. The formulations contain a nonionic polymer, a nonionic surfactant and an ionic tonicity agent, but are physically stable and easily re-suspended. The formulations are intended for topical application to the eye, ear or nose.
Claims10
A topically administrable suspension composition intended for application to the eye, ear or nose comprising
- a) 0.01-0.5% (wt.) dexamethasone;
- b) 0.1-0.4% (wt.) ciprofloxacin;
- c) a tonicity agent consisting essentially of NaCl in an amount sufficient to cause the composition to have an osmolality of about 250-350 mOsm;
- d) 0.1-0.5% (wt.) of a nonionic polymer;
- e) 0.01-0.2% (wt.) of a nonionic surfactant;
- and
- f) a buffer,
- wherein the composition has a pH from about 3-5.
5 more elements
A topically administrable suspension composition intended for application to the eye, ear or nose consisting essentially of
- a) 0.1% (wt.) dexamethasone alcohol;
- b) 0.35% (wt.) ciprofloxacin hydrochloride, monohydrate;
- c) NaCl in an amount sufficient to cause the composition to have an osmolality of about 250-350 mOsm;
- d) 0.2% (wt.) hydroxyethyl cellulose;
- e) 0.05% (wt.) tyloxapol;
- f) a buffer comprising sodium acetate and acetic acid;
- g) 0.01% (wt.) benzalkonium chloride;
- h) 0.01% (wt.) edetate disodium;
- i) 0.6% (wt.) boric acid;
- and
- wherein the composition has a pH of about 4.5.
8 more elements
Dependencies are inferred from the claim text.