Thromboresistant coating composition
AssigneeMedtronic AVE, Inc.
InventorsChirag B. Shah, Laurel L. Wolfgang
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Abstract
Coatings are provided in which biopolymers may be covalently linked to a substrate. Such biopolymers include those that impart thromboresistance and/or biocompatibility to the substrate, which may be a medical device. Coatings disclosed herein include those that permit coating of a medical device in a single layer, including coatings that permit applying the single layer without a primer. Suitable biopolymers include heparin complexes, and linkage may be provided by a silane having isocyanate functionality.
Claims59
A coating, comprising:
- a silane and
- a biopolymer, wherein said biopolymer is covalently linked to the silane.
A coating for a medical device, wherein thromboresistance activity can be modified, comprising
- heparin-tridodecylmethylammonium chloride;
- a silane having isocyanate functionality;
- and
- an organic solvent.
A coated medical device, comprising:
- a substrate, and
- a coating derived from heparin-tridodecylmethylammonium chloride, a silane having isocyanate functionality, and an organic solvent.
A method of coating a medical device, comprising covalently bonding a heparin to the medical device.
A method of coating a medical device, comprising:
- dissolving heparin-tridodecylmethylammonium chloride and a silane having isocyanate functionality in an organic solvent and applying said solution to the device to form a coating on the medical device.
Dependencies are inferred from the claim text.