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US 2001/0034331 A1Published application
EDG family gene, human H218
OwnerDerk J. Bergsma, Nabil Elshourbagy +4inventors
InventorsDerk J. Bergsma, Nabil Elshourbagy, Pamela Lane, Xiaotong Li, Jeffrey L. Mooney, Ping Tsui
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Abstract
Human H218 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human H218 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
Claims14
An isolated polypeptide selected from the group consisting of:
- (i) an isolated polypeptide comprising an amino acid sequence selected from the group having at least:
- (a) 70% identity,
- (b) 80% identity;
- (c) 90% identity;
- or
- (d) 95% identity
- to the amino acid sequence of SEQ ID NO:2 over the entire length of SEQ ID NO:2;
- (ii) an isolated polypeptide comprising the amino acid sequence of SEQ ID NO:2 or
- (iii) an isolated polypeptide which is the amino acid sequence of SEQ ID NO:2.
6 more elements
An isolated polynucleotide selected from the group consisting of:
- (i) an isolated polynucleotide comprising a nucleotide sequence encoding a polypeptide that has at least
- (a) 70% identity;
- (b) 80% identity;
- (c) 90% identity;
- or
- (d) 95% identity;
- to the amino acid sequence of SEQ ID NO:2, over the entire length of SEQ ID NO:2;
- (ii) an isolated polynucleotide comprising a nucleotide sequence that has at least:
- (a) 70% identity
- (b) 80% identity;
- (c) 90% identity;
- or
- (d) 95% identity;
- over its entire length to a nucleotide sequence encoding the polypeptide of SEQ ID NO:2;
- (iii) an isolated polynucleotide comprising a nucleotide sequence which has at least:
- (a) 70% identity;
- (b) 80% identity;
- (c) 90% identity;
- or
- (d) 95% identity;
- to that of SEQ ID NO:1 over the entire length of SEQ ID NO:1;
- (iv) an isolated polynucleotide comprising a nucleotide sequence encoding the polypeptide of SEQ ID NO:2;
- (v) an isolated polynucleotide which is the polynucleotide of SEQ ID NO:1;
- or
- (vi) an isolated polynucleotide obtainable by screening an appropriate library under stringent hybridization conditions with a labeled probe having the sequence of SEQ ID NO:1 or a fragment thereof;
- or a nucleotide sequence complementary to said isolated polynucleotide.
23 more elements
An isolated polynucleotide selected form the group consisting of:
- (a) an isolated polynucleotide comprising a nucleotide sequence which has at least 70%, 80%, 90%, 95%, 97% identity to SEQ ID NO:3 over the entire length of SEQ ID NO:3;
- (b) an isolated polynucleotide comprising the polynucleotide of SEQ ID NO:3;
- (c) the polynucleotide of SEQ ID NO:3;
- or
- (d) an isolated polynucleotide comprising a nucleotide sequence encoding a polypeptide which has at least 70%, 80%, 90%, 95%, 97-99% identity to the amino acid sequence of SEQ ID NO:4, over the entire length of SEQ ID NO:4.
2 more elements
A polypeptide selected from the group consisting of:
- (a) a polypeptide which comprises an amino acid sequence which has at least 70%, 80%, 90%, 95%, 97-99% identity to that of SEQ ID NO:4 over the entire length of SEQ ID NO:4;
- (b) a polypeptide which has an amino acid sequence which is at least 70%, 80%, 90%, 95%, 97-99% identity to the amino acid sequence of SEQ ID NO:4 over the entire length of SEQ ID NO:4;
- (c) a polypeptide which comprises the amino acid of SEQ ID NO:4;
- (d) a polypeptide which is the polypeptide of SEQ ID NO:4;
- (e) a polypeptide which is encoded by a polynucleotide comprising the sequence contained in SEQ ID NO:3.
2 more elements
Dependencies are inferred from the claim text.