Neuroprotective peptides and uses thereof
AssigneeProtarga, Inc.
InventorVictor Shashoua
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Abstract
The invention relates to neuroprotective peptides which bind calcium and which are useful in treating stroke and other neurodegenerative diseases, as well as compositions containing such peptides. The peptides preferably are conjugated to or administered with a compound which facilitates delivery across the blood-brain barrier.
Claims11
a method for increasing neuronal cell AP-1 or NF-IL6 transcription factor activity in a subject, comprising administering to the subject an amount of an isolated peptide which comprises the amino acid sequence of SEQ ID NO:1 effective to increase the activity of AP-1 or NF-IL6 in the subject.
A method for identifying a calcium-binding peptide comprising
- providing a putative calcium-binding peptide,
- contacting the putative calcium-binding peptide with an environment containing calcium, and
- determining the calcium binding of the peptide.
A method for identifying a peptide which increases AP-1 or NF-IL6 transcription factor activity, comprising
- providing a peptide,
- contacting the peptide with a cell which can express AP-1 or NF-IL6 transcription factor activity, and
- determining the AP-1 or NF-IL6 transcription factor activity to identify the peptide which increases AP-1 or NF-IL6 transcription factor activity.
Dependencies are inferred from the claim text.