# US 2001/0020188 A1 · Selective uptake of materials by bone implants

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2001/0020188 A1
- Document ID: US20010020188A1
- Status: Published application
- Kind: A1
- Application number: 09/778,046
- Filed: 2001-02-05
- Published: 2001-09-06
- Earliest claimed: 1997-10-27
- Inventors: Tom Sander
- Web page: https://patentgrep.com/patent/US20010020188A1

## CPC

- A61L 27/3683: {subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment}
- A61F 2/08: Muscles; Tendons; Ligaments
- A61F 2/0811: {Fixation devices for tendons or ligaments}
- A61F 2/28: Bones
- A61F 2/30965: {Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping}
- A61F 2/4241: {for hands, e.g. fingers}
- A61L 27/3608: {Bone, e.g. demineralised bone matrix [DBM], bone powder}
- A61L 27/3645: {Connective tissue}
- A61L 27/365: {Bones}
- A61L 27/3662: {Ligaments, tendons}
- A61L 27/3834: {Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells}
- A61L 27/3843: {Connective tissue}
- A61L 27/3847: {Bones}
- A61L 27/386: {Ligaments, tendons}
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61B 17/06166: {Sutures (suture materials A61L17/00; manufacture of artificial threads D01D; treatment of threads D06M)}
- A61B 17/86: Pins or screws {or threaded wires; nuts therefor (A61B17/72 take precedence)}
- A61F 2/2846: {Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects (nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006)}
- A61F 2/2875: {Skull or cranium (A61F2/2803 takes precedence; joints for temporo-mandibular [TM] joints [TMJ] A61F2/3099)}
- A61F 2/30771: {applied in original prostheses, e.g. holes or grooves}
- A61F 2/3094: {Designing or manufacturing processes}
- A61F 2/442: {Intervertebral or spinal discs, e.g. resilient (non-disc-shaped intervertebral inflatable pockets A61F2/441; non-disc-shaped intervertebral fusion implants A61F2/4455)}
- A61F 2/4455: {for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages (intervertebral discs A61F2/442)}
- A61F 2/4465: {having a circular or kidney shaped cross-section substantially perpendicular to the axis of the spine}
- A61F 2002/0829: {without deformation of anchor parts, e.g. fixation screws on bone surface, extending barbs, cams, butterflies, spring-loaded pins}
- A61F 2002/0858: {Fixation of tendon or ligament between anchor and bone, e.g. interference screws, wedges}
- A61F 2002/087: {Anchor integrated into tendons, e.g. bone blocks, integrated rings}
- A61F 2002/0882: {Anchor in or on top of a bone tunnel, i.e. a hole running through the entire bone}
- A61F 2002/2817: {Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]}
- A61F 2002/2839: {Bone plugs or bone graft dowels}
- A61F 2002/30009: {differing in fibre orientations}
- A61F 2002/30016: {differing in hardness, e.g. Vickers, Shore, Brinell}
- A61F 2002/30059: {differing in bone mineralization, e.g. made from both mineralized and demineralized adjacent parts}
- A61F 2002/30113: {circular}
- A61F 2002/30125: {elliptical or oval}
- A61F 2002/30131: {horseshoe- or crescent- or C-shaped or U-shaped}
- A61F 2002/30153: {rectangular}
- A61F 2002/30156: {triangular}
- A61F 2002/30172: {T-shaped}
- A61F 2002/30179: {X-shaped}
- A61F 2002/302: {toroidal, e.g. rings}
- A61F 2002/30224: {cylindrical}
- A61F 2002/30228: {Cylinders of elliptical or oval basis}
- A61F 2002/3023: {wedge-shaped cylinders}
- A61F 2002/30235: {tubular, e.g. sleeves}
- A61F 2002/30261: {parallelepipedal}
- A61F 2002/30265: {Flat parallelepipeds}
- A61F 2002/30266: {wedge-shaped parallelepipeds}
- A61F 2002/30293: {Cylindrical body made by spirally rolling up a sheet or a strip around itself}
- A61F 2002/30563: {having elastic means or damping means, different from springs, e.g. including an elastomeric core or shock absorbers}
- A61F 2002/30594: {slotted, e.g. radial or meridian slot ending in a polar aperture, non-polar slots, horizontal or arcuate slots}
- A61F 2002/30677: {Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body}
- A61F 2002/30772: {Apertures or holes, e.g. of circular cross section}
- A61F 2002/30774: {internally-threaded}
- A61F 2002/30784: {Plurality of holes}
- A61F 2002/30787: {inclined obliquely with respect to each other}
- A61F 2002/3082: {Grooves}
- A61F 2002/30828: {parallel}
- A61F 2002/30831: {perpendicular with respect to each other}
- A61F 2002/3085: {with a threaded, e.g. self-tapping, bone-engaging surface, e.g. external surface}
- A61F 2002/30878: {with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts}
- A61F 2002/30879: {Ribs}
- A61F 2002/30892: {parallel}
- A61F 2002/30904: {serrated profile, i.e. saw-toothed}
- A61F 2002/30971: {Laminates, i.e. layered products}
- A61F 2002/4251: {for metacarpo-phalangeal joints, i.e. MCP or MP joints, e.g. knuckle joints}
- A61F 2002/4649: {Bone graft or bone dowel harvest sites}
- A61F 2230/0006: circular
- A61F 2230/0008: elliptical or oval
- A61F 2230/0013: Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
- A61F 2230/0019: rectangular
- A61F 2230/0023: triangular
- A61F 2230/0052: T-shaped
- A61F 2230/0058: X-shaped
- A61F 2230/0065: toroidal, e.g. ring-shaped, doughnut-shaped
- A61F 2230/0069: cylindrical
- A61F 2230/0082: parallelepipedal
- A61F 2230/0091: helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
- A61F 2240/001: Designing or manufacturing processes
- A61F 2250/0019: differing in hardness, e.g. Vickers, Shore, Brinell
- A61F 2250/0028: differing in fibre orientations
- A61L 2300/252: Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L 2300/258: Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
- A61L 2300/406: Antibiotics
- A61L 2300/41: Anti-inflammatory agents, e.g. NSAIDs
- A61L 2430/02: for reconstruction of bones; weight-bearing implants
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

This invention provides a novel unitary bone implant having at least one rigid, mineralized bone segment, which may be machined to include threads, grooves, a driver head, perforations, a recess or a symmetric or asymmetric shape, and a flexible, demineralized segment, which may also be machined to any desired shape prior to demineralization, or after demineralization. The implant of this invention has wide orthopedic applicability, including but not limited to repair or replacement of ligaments, tendons and joints and for inducing vertebral fusions and fractured bone repair. In a particular embodiment of this invention, selective uptake of biologically active or inactive materials into the segmentally demineralized portion of the implant is disclosed.

## Claims

### Claim 1

A segmentally demineralized bone implant designed for implantation in a patient, said implant comprising at least one mineralized segment, and at least one demineralized segment, wherein said demineralized segment is modified by selective uptake of a cell, or biologically active or inert molecule.

### Claim 2 (depends on 1)

The implant according to claim 1 wherein said demineralized segment is modified by selective uptake of cells, blood components, growth factors, nucleic acids, proteins, peptides, antibiotics, antineoplastics, anti-inflammatory compounds, and combinations thereof.

### Claim 3 (depends on 1)

The implant of claim 1, wherein said implant is derived from cortical, corticocancellous, cancellous bone, or combinations thereof.

### Claim 4 (depends on 2)

The implant of claim 2 wherein said cells are mesenchymal stem cells (MSC's).

### Claim 5 (depends on 2)

The implant of claim 2 wherein said growth factors are bone morphogenetic proteins, (BMPs), fibroblast growth factors (FGFs), platelet derived growth factor (PDGF), cartilage derived morphogenetic proteins (CDMPs), tissue derived growth factors (TGFs), and combinations thereof.

### Claim 6 (depends on 2)

The implant according to claim 2 wherein said biologically active compound is selected from the group consisting of nucleic acids, proteins, peptides, antibiotics, antineoplastics, anti-inflammatory compounds, and combinations thereof.

### Claim 7

A method of repairing damaged tissue in a patient, human or non-human, in need thereof which comprises implanting in said patient an implant comprising a segmentally demineralized bone implant designed for implantation in a patient, said implant comprising at least one mineralized segment, and at least one demineralized segment, wherein said demineralized segment is modified by selective uptake of a cell, or biologically active or inert molecule.

### Claim 8

A method of making a biological implant which comprises segmentally demineralizing a portion of bone, either before or after machining said bone into any desirable shape for implantation into a patient, human or animal, in need thereof, contacting said segmentally demineralized implant with a composition containing a substance the infusion of which into said demineralized portion of said bone implant is desired, and implanting the thus-treated implant into said patient in need thereof.

### Claim 9 (depends on 8)

An implant made by the process of claim 8.

### Claim 10

A method of treating a disease condition which comprises removal of diseased or damaged tissue and implanting in place thereof a segmentally demineralized bone implant designed for implantation in a patient, said implant comprising at least one mineralized segment, and at least one demineralized segment, wherein said demineralized segment is modified by selective uptake of a cell, or biologically active or inert molecule, or combinations thereof.

### Claim 11 (depends on 10)

The method according to claim 10 wherein said biologically active molecule is an antibiotic, an antineoplastics, an anti-inflammatory, an antiviral, an antifungal, or a combination of such molecules.