US 2001/0020110 A1 · Production methods of alpha, alpha, alpha-trifluoromethylphenyl-substituted benzoic acid and intermediate therefor

Abstract

The present invention relates to a production method of compound [V] useful as an intermediate for medicaments and agrochemicals. The method includes reacting compound [III] with hexamethylenetetramine under heating to give compound [IV], and oxidizing the obtained compound [IV] with a halous acid salt or a ruthenium compound. According to the present invention, moreover, an organometallic compound having a tolyl group and compound [I] are cross-coupled in the presence of a catalyst to give compound [II] useful as an intermediate for medicaments and agrochemicals. The compound [II] is halogenated to give compound [III]. 1 wherein X is halogen atom.

Claims30

Dependent claims

A production method of α,α,α-trifluoromethylphenyl-substituted benzoic acid, which comprises the steps of

(c) reacting α,α,α-trifluoromethylphenyl-substituted benzyl halide of the formula [III] 11
wherein X is a halogen atom, and hexamethylenetetramine under heating to give α,α,α-trifluoromethylphenyl-substituted benzaldehyde of the formula [IV] 12
and
(d) oxidizing the α,α,α-trifluoromethylphenyl-substituted benzaldehyde with a halous acid salt or a ruthenium compound as an oxidizing agent to give α,α,α-trifluoromethylphenyl-substituted benzoic acid of the formula [V] 13

1 more element

Dependencies are inferred from the claim text.

Production methods of alpha, alpha, alpha-trifluoromethylphenyl-substituted benzoic acid and intermediate therefor

Life of this patent

Production methods of alpha, alpha, alpha-trifluoromethylphenyl-substituted benzoic acid and intermediate therefor

Life of this patent

Abstract

Claims30