Certain fused pyrrolecarboxamides a new class of gaba brain receptor

A compound of the formula:

• 38
• wherein
• R3 and R4 are the same or different and represent hydrogen, alkyl, COR5 or CO2R5 where R5 is alkyl or cycloalkyl having 3-7 carbon atoms, CONR6R7 where R6 and R7 are selected independently from hydrogen, alkyl, cycloalkyl having 3-7 carbon atoms, phenyl, 2-, 3-, or 4-pyridyl, or NR6R7 forms a heterocyclic group which is morpholinyl, piperidinyl, pyrrolidinyl, or N-alkyl piperazinyl;
• or
• R3-R4 together represent a cyclic moiety having 3-7 carbon atoms;
• R8 is hydrogen, halogen, hydroxyl, alkyl, alkoxy, cycloalkyl alkoxy having 3-7 carbon atoms, amino, mono- or dialkylamino;
• and
• R9 is hydrogen, halogen, cyano, hydroxy, alkyl, alkoxy, cycloalkyl alkoxy having 3-7 carbon atoms, amino, mono- or dialkylamino, NR1COR2, COR2, or CO2R2 where R1 and R2 are the same or different and represent hydrogen, alkyl, or cycloalkyl having 3-7 carbon atoms;
• and
• R10 is hydrogen, halogen, hydroxyl, alkyl, alkoxy, amino, mono- or dialkylamino;
• m is 0, 1, or 2;
• and
• n is 0, 1, or 2.

A compound of the formula:

• 39
• where
• G represents thienyl, thiazolyl, pyridyl, napthyridinyl, quinolinyl, or phenyl, each of which is optionally mono-, di- or trisubstituted with halogen, alkyl, alkoxy, or hydroxy;
• and
• R3 and R4 are the same or different and represent hydrogen or alkyl, provided that not both R3 and R4 are hydrogen.