Compositions of optically pure (+) norcisapride
AssigneeSepracor Inc.
InventorsJohn R. McCullough, Thomas P. Jerussi
Life of this patent
Estimating the term…
Abstract
Compositons employing and methods utilizing the optically pure (+) isomer of norcisapride are disclosed. This compound has surprisingly been found to be a potent drug for the treatment of disorders of the central nervous system. The compound, (+) norcisapride, has also been found to be a potent antiemetic agent. Finally, the (+) isomer of norcisapride also avoids certain adverse side effects and certain adverse drug interactions.
Claims24
A method of treating or preventing a disorder caused by gastrointestinal motility dysfunction in a human which comprises administering to said human a therapeutically effective amount of (+) norcisapride, or a pharmaceutically acceptable salt thereof, substantially free of its (−) stereoisomer.
A method of eliciting a prokinetic effect in a human to treat gastro-esophageal reflux disease in said human which comprises administering to said human a therapeutically effective amount of (+) norcisapride, or a pharmaceutically acceptable salt thereof, substantially free of its (−) stereoisomer.
A pharmaceutical composition suitable for administration to a human which comprises (+) norcisapride or a pharmaceutically acceptable salt thereof, substantially free of its (−) stereoisomer;
- and a pharmaceutically acceptable carrier or excipient.
Dependencies are inferred from the claim text.