Combination progestin oral contraceptive regimen
AssigneeOrtho-McNeil Pharmaceutical, Inc.
InventorsMichael Kafrissen, Haya Taitel
Life of this patent
Estimating the term…
Abstract
An oral contraception regimen which comprises sequentially administering two or more progestational agents exhibiting different effects on the human endometrium in combination with an estrogen. The invention is also directed to an extended use oral contraception regimen comprising the sequential administration of two or more progestational agents in combination with an estrogen.
Claims17
A combination progestin and estrogen hormonal method and regimen for human contraception involving the sequential administration of two or more different progestational agents in combination with an estrogen comprising the steps of:
- (a) administering a contraceptively effective amount of an endometrial sparing progestin in combination with an estrogen in single daily doses for a period of 7-14 days followed by;
- (b) administering a contraceptively effective amount of an atrophizing progestin in combination with an estrogen in single daily doses for a period of 7-14 days;
- (c) repeating steps (a) and (b) for a period of 21-90 days;
- (d) withdrawing the administration for a period of about seven days;
- and
- (e) repeating steps (a)-(d) continuously.
An extended use combination progestin and estrogen hormonal method and regimen for human contraception involving the sequential administration of two or more different progestational agents in combination with an estrogen comprising the steps of:
- (a) administering a contraceptively effective amount of an endometrial sparing progestin in combination with an estrogen in single daily doses for a period of 7-14 days, followed by;
- (b) administering a contraceptively effective amount of an atrophizing progestin in combination with an estrogen in single daily doses for a period of 7-14 days;
- (c) repeating steps (a) and (b) for a period of 90 days;
- (d) withdrawing the administration for a period of about seven days;
- and
- (e) repeating steps (a)-(d) continuously.
A drug delivery system comprising a pharmaceutical package containing 21 separate dosage units, adapted for successive daily oral administration comprising:
- 7-14 dosage units, containing, in admixture with a pharmaceutical acceptable carrier, a combination of a contraceptively effective amount of an endometrial sparing progestin and an estrogen;
- followed by 7-14 dosage units, containing, in admixture with a pharmaceutical acceptable carrier, a combination of a contraceptively effective amount of an atrophizing progestin and an estrogen, such that the total number of dosage units equals 21.
Dependencies are inferred from the claim text.