Analogs of human basic fibroblast growth factor
Assignee3-Dimensional Pharmaceuticals, Inc.
InventorsBarry A. Springer, Michael W. Pantoliano, Celia M. Sharp
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Abstract
The present invention relates to novel muteins of human basic fibroblast growth factor with superagonist properties. Both protein and the respective encoding nucleic acid species are disclosed. The invention also embodies vectors and host cells for the propagation of said nucleic acid sequences and the production of said muteins. Also disclosed are methods for stimulating cell division, treating a wound, treating ischemia, treating heart disease, treating neural injury, treating peripheral vascular disease, treating a gastric ulcer and treating a duodenal ulcer.
Claims47
A mutein of human basic fibroblast growth factor, or a biologically active peptide thereof, comprising the substitution of a neutral and/or hydrophobic amino acid for one or more of the following:
- (a) Glutamate 89;
- or
- (b) Aspartate 101;
- or
- (c) Leucine 137.
Dependencies are inferred from the claim text.