Loading patent…
AssigneeThe Regents of the University of California
InventorsWillem F. Wolkers, John H. Crowe, Fern Tablin, Ann E. Oliver, Naomi J. Walker
Estimating the term…
A dehydrated composition is provided that includes freeze-dried platelets. The platelets are loaded with trehalose which preserves biological properties during freeze-drying and rehydration. The trehalose loading is conducted at a temperature of from greater than about 25° C. to less than about 40° C., most preferably at 37° C., with the loading solution having trehalose in an amount from about 10 mM to about 50 mM. These freeze-dried platelets are substantially shelf-stable and are rehydratable so as to have a normal response to an agonist, for example, thrombin, with virtually all of the platelets participating in clot formation within about three minutes at 37° C.
A dehydrated composition, useful for mammalian therapy, comprising:
A therapeutic composition, comprising:
A hemostasis aid, comprising:
A process of preparing a dehydrated composition, useful for therapy to a mammal, comprising:
A therapeutic process of using a dehydrated composition, comprising:
Dependencies are inferred from the claim text.