Use of metal chelates as radiosensitizers
OwnerWerner Krause, Ruediger Lawaczeckinventors
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Abstract
The invention relates to compounds useful as radiosensitizers in tumor therapy.
Claims16
A method of using metal chelates for the preparation of pharmaceutical compositions suitable for tumor therapy comprising metal chelates with metal ions of atomic numbers 20-32, 39-51 or 57-83 and polyaminopolycarboxylic acids as chelate forming ligand.
A method of using metal chelates for the preparation of pharmaceutical compositions suitable for radiation therapy of hypoxic tumors comprising metal chelates with metal ions of atomic numbers 20-32, 39-51 or 57-83 and polyaminopolycarboxylic acids as chelate forming ligand.
A method of using metal chelates for the diagnosis and/or therapy of hypoxia comprising a metal chelate with metal ions of atomic numbers 20-32, 39-51 or 57-83 and a polyaminopolycarboxylic acid as chelate forming ligand.
A method of using metal chelates for the diagnosis and/or therapy of hypoxia tumors comprising a metal chelate with metal ions of atomic numbers 20-32, 39-51 or 57-83 and a polyaminopolycarboxylic acid as chelate forming ligand.
A method of using metal chelates for the diagnosis and/or therapy of ischemia comprising a metal chelate with metal ions of atomic numbers 20-32, 39-51 or 57-83 and a polyaminopolycarboxylic acid as chelate forming ligand.
A method of using metal chelates for the diagnosis and/or therapy of necrosis comprising a metal chelate with metal ions of atomic numbers 20-32, 39-51 or 57-83 and a polyaminopolycarboxylic acid as chelate forming ligand.
A method of using metal chelates for the simultaneous or subsequent diagnosis and therapy of tumors comprising a metal chelate with metal ions of atomic numbers 20-32, 39-51 or 57-83 and a polyaminopolycarboxylic acid as chelate forming ligand.
A method of using metal chelates according to previous claims comprising the chelators EDTA, DTPA, EOB-DTPA, BOPTA, 3,6,9-triaza-3,6,9-tris(carboxymethyl)-undecaneacid-bis-methylamide, 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-butylbenyl)-undecaneacid, 3,6,9-triaza-3,6,9-tris(carboxymethyl)-undecaneacid-bis-methytamide, 3,6,9-triaza-3,6,9-tris(carboxymethyl)-undecaneacid-bis-morpholid, 3,6,9triaza-3,6,9-tris(carboxymethyl)-undecaneacid-bis-(ω-carboxylato)undecylamide as polyaminopolycarboxylic acid or a substituted derivative thereof.
A method of using metal chelates according to previous claims comprising the chelators DOTA, DO3A, Butriol or a substituted derivative thereof as polyaminopolycarboxylic acid.
A method of using metal chelates according to previous claims comprising a polyaminopolycarboxylic acid with at least one lipophilic substituent.
A method of using metal chelates according to previous claims for the preparation of diagnostics and therapeutics.
Dependencies are inferred from the claim text.