Continuously regenerated and integrated suppressor and detector for suppressed ion chromatography and method
OwnerJames M. Anderson JR., Raaidah Saari-Nordhausinventors
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Abstract
An integrated suppressor and detector for suppressed ion chromatography includes a stationary phase, a fluid flow path, at least first and second regeneration electrodes, and at least first and second sensor electrodes. Methods of suppressed ion chromatography using the integrated suppressor and detector are also described.
Claims24
An integrated suppressor and detector for detecting analyte ions in a sample comprising:
- (a) a suppressor;
- and
- (b) at least a first sensor electrode and a second sensor electrode positioned in the suppressor for detecting the analyte ions.
A method of conducting suppression ion chromatography wherein a suppressor is continuously regenerated comprising:
- (a) providing a stationary phase comprising suppressor ions;
- (b) providing an aqueous mobile phase comprising analyte ions to be detected;
- (c) performing electrolysis on the mobile phase;
- and
- (d) flowing regenerating ions through the stationary phase.
An integrated suppressor and detector for use in conducting suppression ion chromatography comprising:
- (a) at least a first regeneration electrode and a second regeneration electrode, and a fluid flow path extending between the first and second regeneration electrodes;
- (b) a stationary phase comprising suppressor ions positioned in the fluid flow path;
- (c) at least first and second sensor electrodes positioned in the fluid flow path;
- and
- (d) a measuring device in electrical communication with the first and second sensor electrodes.
A method of detecting analyte ions using suppression ion chromatography comprising:
- (a) providing first and second regeneration electrodes;
- (b) providing a fluid flow path with a stationary phase comprising suppressor ions selected from the group consisting of hydronium ions and hydroxide ions, wherein the fluid flow path extends between the first and second regeneration electrodes;
- (c) providing a first sensor electrode and a second sensor electrode positioned in the fluid flow path;
- (d) converting the analyte ions in the fluid flow path to either their acid or base;
- and
- (e) detecting the converted analyte ions in the fluid flow path with the sensor electrodes.
A method of conducting suppression ion chromatography comprising:
- (a) providing a stationary phase comprising suppressor ions selected from the group consisting of hydronium ions and hydroxide ions, wherein at least a portion of the stationary phase is positioned in a fluid flow path positioned between a first regeneration electrode and a second regeneration electrode;
- (b) providing an aqueous mobile phase comprising analyte ions to be detected, analyte counterions and electrolyte;
- (c) flowing the mobile phase through the stationary phase;
- (d) suppressing the mobile phase by ion exchange of the electrolyte with the suppressor ions of the stationary phase;
- (e) converting the analyte ions in the fluid flow path to their acid or base by ion exchange of the analyte counterions ions with the suppressor ions of the stationary phase;
- (f) detecting the acid or base of the analyte ions located in the fluid flow path;
- and
- (g) regenerating the stationary phase during step (c) by performing electrolysis on the mobile phase.
A method of conducting suppression ion chromatography wherein a mobile phase is regenerated comprising:
- (a) flowing a mobile phase comprising electrolyte to a suppressor;
- (b) suppressing the mobile phase by ion exchange of the electrolyte with suppressor ions selected from the group consisting of hydronium ions and hydroxide ions;
- and
- (c) combining the electrolyte with regeneration ions selected from the group consisting of hydroxide ions and hydronium ions.
Dependencies are inferred from the claim text.