Synthesis and pharmaceuticals of novel 9-substituted-1, 5-dichloroanthracene analogs

A method for synthesis of 9-substituted-1,2-dichloroanthrecene derivatives, comprising reacting 1,5-dichloroanthrone with an acyl chloride under weakly basic conditions to give a 9-acyloxy-1,5-dichloroanthrancene according to Formula III 4

• wherein R represents a straight or branched chain alkyl group having 1 to 6 carbons which may be substituted with one or more groups R1, or R represents a phenyl or benzyl group which may be substituted with one or two groups R2;
• wherein R1 is selected from the group consisting of halogen, —NO2, —OCH3, OCH2CH3, and —OCH2CH2CH3;
• and
• wherein R2 is selected from the group consisting of a straight or branched chain alkyl group having 1 to 4 carbons, halogen, —NO2, —OCH3, —OCH2CH3, and —OCH2CH2CH3.

A pharmaceutical compound which is synthesized by reacting 1,5-dichloroanthrone with an acyl chloride of the form RC(O)Cl under a weakly basic condition;

• wherein R represents a straight or branched chain alkyl group having 1 to 6 carbons which may be substituted with one or more groups R1, or R represents phenyl or benzyl which may be substituted with one or two groups R2;
• wherein R1 is a group selected from halogen, —NO2, —OCH3, —OCH2CH3, and —OCH2CH2CH3;
• and
• wherein R2 is a group selected from a straight or branched chain alkyl group having 1 to 4 carbons, halogen, —NO2, —OCH3, —OCH2CH3, and —OCH2CH2CH3.