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US 2001/0018531 A1Published application
Water soluble analogs and prodrugs of paclitaxel
OwnerPeter H.G. Wiegerinck, Duncan Sperling +4inventors
InventorsPeter H.G. Wiegerinck, Duncan Sperling, Lesly Braamer, Eric W.P. Damen, Johan W. Scheeren, Dick de Vos
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Abstract
The invention relates to water soluble antitumor analogs of paclitaxel of formula (I) wherein R1═C(O)CH2CH(OH)COOX, R2═H, C(O)CH2CH(OH)COOX, X═H, Li, Naa or any other pharmaceutically acceptable counterion, as well as to a pharmaceutical composition comprising an antineoplastically effective amount of such analogs as an active ingredient.
Claims4
Water soluble antitumor analogs of paclitaxel having the following formula:
- 4
- Wherein:
- R1═C(O)CH2CH(OH)COOX,
- R2═H. C(O)CH2CH(OH)COOX,
- X═H, Li, Na or any other pharmaceutically acceptable counterion.
2 more elements
Dependencies are inferred from the claim text.