Back to results
US 2001/0018523 A1Published application
Sulfonamide compounds and methods of treating atherosclerosis and restenosis
AssigneeWarner-Lambert Company
InventorsHelen Tsenwhei Lee, Randy Ranjee Ramharack, Bruce David Roth, Karen Elaine Sexton
Life of this patent
Estimating the term…
Abstract
The present invention provides compounds having the Formula I 1 The present invention also provides methods of treating or preventing atherosclerosis, coronary heart disease, and restenosis using the compounds of Formula I, and pharmaceutical compositions comprising the compounds of Formula I.
Claims16
A compound of the Formula I 30
- wherein
- R1 is heteroaryl, substituted heteroaryl, —(CH2)n—C3-C8 cycloalkyl, —(CH2)n-aryl or —(CH2)n-substituted aryl;
- R2 is C1-C6 alkyl, heteroaryl, substituted heteroaryl, aryl, substituted aryl, 31
- n is 0 to 4, and the pharmaceutically acceptable salts thereof.
1 more element
A compound of the Formula I 36
- wherein
- R1 is pyridyl, —CH2 cyclohexyl, or -substituted pyridyl;
- R2 is -thienyl-pyridyl, —C1-C6 alkyl, substituted phenyl, thienyl, or —CH2-phenyl;
- R3 is 37
- and the pharmaceutically acceptable salts thereof.
2 more elements
The compounds
- 5-pyridin-2-yl-thiophene-2-sulfonic acid (3,5-di-tert-butyl-4-hydroxy-benzyl)-pyridin-3-yl-amido;
- (Cyclohexylmethyl-methanesulfonyl-amino)-(3,5-di-tert-butyl-4-hydroxy-phenyl)-acetic acid ethyl ester;
- N-(3,5-Di-tert-butyl-4-hydroxy-benzyl)-4-methyl-N-pyridin-3-yl-benzenesulfonamide;
- N-(3,5-Di-tert-butyl-4-hydroxy-benzyl)-4-fluoro-N-pyridin-3-yl-benzenesulfonamide;
- N-(3,5-Di-tert-butyl-4-hydroxy-benzyl)-4-nitro-N-pyridin-3-yl-benzenesulfonamide;
- Thiophene-2-sulfonic acid (3,5-di-tert-butyl-4-hydroxy-benzyl)-6-methoxy-pyridin-3-yl-amide
- Thiophene-2-sulfonic acid (3,5-di-tert-butyl-4-hydroxy-benzyl)-pyridin-3-yl-amide;
- N-(3,5-Di-tert-butyl-4-hydroxy-benzyl)-4-acetamido-N-pyridin-3-yl-benzene sulfonamide;
- N-(3,5-Di-tert-butyl-4-hydroxy-benzyl)-4-methoxy-N-pyridin-3-yl-benzenesulfonamide;
- N-(3,5-Di-tert-butyl-4-hydroxy-benzyl)-3-nitro-N-pyridin-3-yl-benzenesulfonamide;
- N-(3,5-Di-tert-butyl-4-hydroxy-benzyl)-3-N-pyridin-3-yl-benzenesulfonamide;
- N-(3,5-Di-tert-butyl-4-hydroxy-benzyl)-N-pyridin-3-yl-methanesulfonamide;
- N-(2-Chloro-pyridin-3-yl)-N-(3,5-di-tert-butyl-4-hydroxy-benzyl)-4-methyl-benzenesulfonamide;
- N-(3,5-di-tert-butyl-4-hydroxybenzyl)-2-bromo-N-pyridin-3-yl-benzenesulfonamide;
- N-(6-Chloro-pyridin-3-yl)-N-(3,5-di-tert-butyl-4-hydroxybenzyl)-4-methyl-benzenesulfonamide;
- N-(3,5-di-tert-butyl-4-hydroxybenzyl)-2-naphthalene-N-pyridin-3-yl-sulfonamide;
- N-(3,5-di-tert-butyl-4-hydroxy-benzyl)-N-(6-methoxy-pyridin-3-yl)-4-methyl-benzenesulfonamide;
- and
- N-(3,5-di-tert-butyl-4-hydroxybenzyl)-3-bromo-N-pyridin-3-yl-benzenesulfonamide.
16 more elements
Dependencies are inferred from the claim text.