Aminotriazole compounds

A compound selected from those of formula (I):

• 17
• wherein:
• n is 0 or 1,
• W represents —CO— or S(O)q wherein q is 0, 1 or 2,
• the grouping 18
• represents a group selected from:
• 19
• Z represents alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, optionally substituted arylalkenyl, optionally substituted arylalkynyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl or optionally substituted heteroarylalkyl,
• A represents a grouping selected from -A2-, -A1-A2-, -A2-A1- and -A1-A2-A1- wherein A1 is alkylene and A2 represents optionally substituted phenylene, optionally substituted naphthylene, cycloalkylene, or optionally substituted heteroarylene,
• R represents hydrogen, alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, optionally substituted arylalkenyl, optionally substituted arylalkynyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl or optionally substituted heteroarylalkyl,
• R1 represents alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylalkyl, optionally substituted arylalkenyl, optionally substituted arylalkynyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl or optionally substituted heteroarylalkyl,
• their enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically-acceptable acid or base,
• it being understood that
• the term “alkyl” denotes a linear or branched group having from 1 to 6 carbon atoms,
• the term “alkylene” denotes a linear or branched bivalent radical containing from 1 to 6 carbon atoms,
• the term alkenyl denotes a linear or branched group having from 2 to 6 carbon atoms and from 1 to 3 double bond,
• the term alkynyl denotes a linear or branched group having from 2 to 6 carbon atoms and from 1 to 3 triple bond,
• the term “aryl” denotes phenyl, naphthyl, biphenyl, dihydronaphthyl or tetrahydronaphthyl,
• the term “heteroaryl” denotes an unsaturated or partially unsaturated mono- or bi-cyclic group having from 5 to 11 ring members, containing from 1 to 4 hetero atoms selected from nitrogen, oxygen and sulphur,
• the terms “phenylene” and “naphthylene” denote bivalent phenyl and naphthyl radicals, respectively,
• the term cycloalkylene denotes a bivalent saturated cyclic radical having from 3 to 8 carbon atoms,
• the term “heteroarylene” denotes a bivalent heteroaryl radical as defined hereinbefore,
• the expression “optionally substituted” applied to the terms “aryl”, “arylalkyl”, “heteroaryl” or “heteroarylalkyl” means that those groups are substituted on their cyclic moiety by from 1 to 5 identical or different substituents selected from linear or branched (C1-C6)alkyl, linear or branched (C1-C6)alkoxy, halogen, hydroxy, linear or branched perhalo-(C1-C6)alkyl, nitro, amino (optionally substituted by one or two linear or branched (C1-C6)alkyl), linear or branched (C1-C6)acyl, aminocarbonyl (optionally substituted on the nitrogen atom by one or two linear or branched (C1-C6)alkyl), linear or branched (C1-C6)acylamino, linear or branched (C1-C6)alkoxycarbonyl, formyl, carboxy, sulpho, nitrile, linear or branched (C1-C6)aminoalkyl (optionally substituted on the nitrogen atom by one or two linear or branched (C1-C6)alkyl), linear or branched (C1-C6)thioalkyl (optionally substituted on the sulfur atom by a linear or branched (C1-C6)alkyl), or linear or branched (C1-C6)hydroxyalkyl (optionally substituted on the oxygen atom by a linear or branched (C1-C6)alkyl),
• the expression “optionally substituted” applied to the terms “phenylene”, “naphthylene” or “heteroarylene” means that those groups are substituted by from one to three identical or different groups selected from linear or branched (C1-C6)alkyl, linear or branched (C1-C6)alkoxy, halogen, hydroxy, linear or branched perhalo-(C1-C6)alkyl, nitro, amino (optionally substituted by one or two linear or branched (C1-C6)alkyl), linear or branched (C1-C6)acyl, formyl, carboxy, linear or branched (C1-C6)alkoxycarbonyl, aminocarbonyl (optionally substituted on the nitrogen atom by one or two linear or branched (C1-C6)alkyl), linear or branched (C1-C6)acylamino and nitrile.