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US 2001/0018519 A1Published application
Preparation of opiates
AssigneeJohnson Matthey Public Limited Company
InventorAlice Sebastian
Life of this patent
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Abstract
A novel process for the preparation of codeinone and analogues thereof comprising the oxidation of a compound of formula, 1 or a salt thereof, wherein R1 is lower alkyl or a group 2 wherein R4 is lower alkyl, lower alkyl substituted by halogen or phenyl, phenyl or substituted phenyl; and R2 is lower alkyl, allyl or lower alkyl substituted by cycloalkyl, characterised in that the oxidation is carried out in an acidic environment is disclosed.
Claims9
A process for the preparation of a compound of formula (I) 6
- wherein R1 is lower alkyl or a group 7
- wherein R4 is lower alkyl, lower alkyl substituted by halogen or phenyl. phenyl or substituted phenyl;
- and
- R2 is lower alkyl, allyl or lower alkyl substituted by cycloalkyl;
- comprising the oxidation of a compound of formula (II), 8
- or a salt thereof, wherein R1 and R2 are as hereinbefore defined, characterised in that the oxidation is carried out in an acidic environment:
3 more elements
Dependencies are inferred from the claim text.