Ethylene vinyl alcohol composition and coating
AssigneeAdvanced Cardiovascular Systems, Inc.
InventorsYung-Ming Chen, Ashok Shah, Vinayak D. Bhat, Syed F.A. Hossainy, Daryush Mirzaee, Evgenia Mandrusov, Deborra Sanders-Millare, Judy A. Guruwaiya
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Abstract
An ethylene vinyl alcohol coating for an implantable device or prosthesis, such as a stent, is provided. Compositions are also provided for coating the implantable device. The compositions can include an ethylene vinyl alcohol copolymer added to an iso-propyl alcohol (IPA)/water solvent. Active agents, such as actinomycin D, can be included in the composition to be carried by the copolymer matrix.
Claims27
A coating for a prosthesis, comprising an ethylene vinyl alcohol copolymer, wherein the copolymer can be dissolved when added to a solvent comprising iso-propyl alcohol and water.
A therapeutic composition for inhibiting the narrowing of a region of a blood vessel, comprising an ethylene vinyl alcohol copolymer and an active agent,
- wherein the copolymer comprises a mole percent of ethylene of about 27% to about 29%, and
- wherein the active agent is released from the copolymer to inhibit the narrowing of a region of a blood vessel.
A method of forming a coating for a prosthesis, comprising the acts of:
- applying a composition comprising an ethylene vinyl alcohol copolymer and a solvent to the prosthesis to form a coating, the solvent comprising iso-propyl alcohol and water, wherein the coating is formed when the solvent is allowed to be essentially removed from the composition.
A stent comprising a generally tubular structure coated with an ethylene vinyl alcohol copolymer.
A solution for coating a medical device comprising:
- (a) an amount of iso-propyl alcohol and water solvent;
- and
- (b) an amount of an ethylene vinyl alcohol copolymer dissolved in the solvent.
Dependencies are inferred from the claim text.