Steroid sulphatase inhibitors

A ring system compound;

• wherein the ring system compound comprises a ring to which is attached a sulphamate group of the formula 16
• wherein each of R1 and R2 is independendy selected from H, alkyl, alkenyl, cycloalkyl and aryl, or together represent alkylene optionally containing one or more hetero atoms or groups in the allylene chain;
• wherein R1 or R2 is H;
• wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (E.C.3.1.6.2);
• and
• wherein if the sulphamate group of said compound is replaced with a sulphate group to form a sulphate compound it would be a substrate for a steroid sulphatase enzyme (E.C.3. 1.6.2).

A ring system compound;

• wherein the ring system compound comprises a ring to which is attached a sulphamate group of the formula 17
• wherein each of R1 and R2 is independently selected from H, alkyl, alkenyl, cycloalkyl and aryl, or together represent alylene optionally containing one or more hetero atoms or groups in the allylene chain;
• wherein R1 or R2 is H;
• wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (E.C.3.1.6.2);
• and
• wherein if the sulphamate group of said compound is replaced with a sulphate group to form a sulphate compound and incubated with a steroid sulphatase enzyme (E.C.3.1.6.2) at a pH 7.4 and 37° C. it would provide a Km value of less than 50 μM.

A ring system compound;

• wherein the ring system compound has the formula 18
• wherein each of R1 and R2 is independently selected from H, alkyl, alkenyl, cycloalkyl and aryl, or together represent alkylene optionally containing one or more hetero atoms or groups in the alllylene chain;
• wherein R1 or R2 is H;
• wherein the group Poly cycle is a polycyclic ring structure
• wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (E.C.3.1.6.2);
• and
• wherein if the sulphamate group of said compound is replaced with a sulphate group to form a sulphate compound it would be a substrate for a steroid sulphatase enzyme (E.C.3.1.6.2).

A ring system compound;

• wherein the ring system compound has the formula 19
• wherein each of R1 and R2 is independently selected from H, alkyl, alkenyl, cycloalkyl and aryl, or together represent alkylene optionally containing one or more hetero atoms or groups in the alkylene chain;
• wherein R1 or R2 is H;
• wherein the group Poly cycle is a steroidal ring structure
• wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (EC.3.1.6.2);
• and
• wherein if the sulphamate group of said compound is replaced with a sulphate group to form a sulphate compound it would be a substrate for a steroid sulphatase enzyme (E.C.3.1.6.2).