Compositions and methods for inhibiting cellular proliferation
AssigneeEntreMed, Inc.
InventorsAdonia E. Papathanassiu, Shawn J. Green
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Abstract
Compositions and methods for inhibiting cellular proliferation wherein the composition contains Tissue Factor Pathway Inhibitor (TFPI), a TFPI homolog, or an active fragment thereof. TFPI exhibits potent anti-proliferative activity on human and other animal cells, particularly endothelial cells. More particularly, the TFPI, TFPI homolog, and inhibitory fragment thereof may be combined with a pharmaceutically acceptable excipient or carrier and used to inhibit angiogenesis and angiogenesis-related diseases such as cancer, arthritis, macular degeneration, and diabetic retinopathy.
Claims20
A method of treating a human or animal having undesirable cell proliferation comprising,
- administering to the human or animal a sufficient amount of a composition comprising tissue factor pathway inhibitor to inhibit the undesirable cell proliferation.
A composition for inhibiting cell proliferation comprising tissue factor pathway inhibitor in a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.