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AssigneesGenencor International, Inc., J. Bryan Jones
InventorsBRYAN J. JONES, BENJAMIN G. DAVIS
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The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine in a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also, a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins.
A chemically modified mutant protein, said mutant protein comprising a cysteine residue substituted for a residue other than cysteine in a precursor protein, the substituted cysteine residue being subsequently modified by reacting said cysteine residue with a glycosylated thiosulfonate.
A method of producing a chemically modified mutant protein comprising the steps of:
A glycosylated thiosulfonate comprising:
A method of modifying the functional characteristics of a protein comprising:
Dependencies are inferred from the claim text.