Monoclonal antibodies directed against the microtubule-associated protein tau
AssigneeInnogenetics N.V.
InventorsMarc Mercken, Eva-Maria Mandelkow, Marc Vandermeeren, Eugeen Vanmechelen, Van De Voorde Andre
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Abstract
A monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to human abnormally phosphorylated tau protein. The tau protein ca be obtained from a brain homogenate, itself isolated from the cerebral cortex of a patient having Alzheimer's disease.
Claims19
Monoclonal antibody which forms an immunological complex with a phosphorylated epitope of an antigen belonging to human abnormally phosphorylated tau protein, with said tau protein being liable to be obtained from a brain homogenate, itself isolated from the cerebral cortex obtained from a patient having Alzheimer's disease or having died of Alzheimer's disease.
Monoclonal antibody secreted by the hybridoma deposited at ECACC on Oct. 8, 1991 under No. 91100806.
Abnormally phosphorylated tau protein characterized such as obtained from normal tau protein which is subjected to phosphorylation by any kinase which is capable of phosphorylation of normal tau at the positions marked with * in the normal tau amino acid sequence 15
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