Process for producing sustained-release preparation
OwnerTakada Shigeyuki, Taira Keiko +1inventors
InventorsTakada Shigeyuki, Taira Keiko, Iwasa Susumu
Life of this patent
Estimating the term…
Abstract
The present invention is to provide sustained-release microcapsules which contains high amount of a drug, suppresses initial release and shows stable release, and the production method of which comprises adding a physiologically active substance to biodegradable polymer in an organic solvent containing a fat and oil (in particular, vitamin E) and dispersing and emulsifying the mixture.
Claims27
A process for producing a sustained-release microcapsule of a water-soluble physiologically active substance, which comprises forming a w/o type emulsion comprising a solution containing a water-soluble physiologically active substance as an inner aqueous phase and an uniform organic solvent solution containing a biodegradable polymer and a fat and oil as an oil phase, and removing the organic solvent.
A process for producing a sustained-release microcapsule, which comprises removing an organic solvent from a S/O type dispersion where a metal complex of a water-soluble physiologically active peptide is dispersed in an uniform organic solvent solution containing a biodegradable polymer and a fat and oil.
Use of a fat and oil for the manufacture of a sustained-release microcapsule of a water-soluble physiologically active substance, said microcapsule being produced by forming a w/o type emulsion comprising a solution containing the water-soluble physiologically active substance as an inner aqueous phase and an organic solvent solution containing a biodegradable polymer as an oil phase, and removing the organic solvent.
Use of a fat and oil for the manufacture of a sustained-release microcapsule of a metal complex of a water-soluble physiologically active peptide.
Dependencies are inferred from the claim text.