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OwnerDavid John Rafter, Robert Murray Ratcliffe +2inventors
InventorsDavid John Rafter, Robert Murray Ratcliffe, Bradley G. Thompson, Glen D. Armstrong
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This invention relates to the treatment of diarrhea and related conditions caused by pathogenic E. coli infection. More specifically, this invention is drawn to the unexpected discovery that by administering a composition which binds and removes the shiga like toxins (SLT) produced by pathogenic E. coli whenever an antibiotic is administered, improved treatment is provided. Novel compositions containing both antibiotic and toxin binding composition and methods of treatment which use simultaneous administration toxin binding composition whenever antibiotic is administered are provided. These compositions and methods kill the enteric E. coli organisms which produce the conditions and neutralize the SLT produced by the organisms and/or released from the organisms when they are killed. Thus, these compositions and methods are better able to ameliorate the symptoms of the infection and inhibit progression of this infection into hemolytic uremic syndrome (HUS) than conventional treatment.
A method to prevent or ameliorate one or more conditions mediated by enterohemorrhagic E. coli in a patient suffering from or susceptible to said condition, comprising simultaneously administering to the patient an effective amount of at least one antibiotic and an effective amount of at least one SLT binding oligosaccharide sequence covalently attached to a pharmaceutically acceptable inert support (oligosaccharide-support), wherein said oligosaccharide sequence binds SLT, and wherein the SLT bound to oligosaccharide-support is capable of being eliminated from the gastrointestinal tract.
A pharmaceutical composition useful in treating or preventing conditions associated with enterohemorrhagic E. coli, comprising:
A method to prevent or ameliorate one or more conditions mediated by enterohemorrhagic E. coli in a patient suffering from or susceptible to said condition, comprising the steps of:
Dependencies are inferred from the claim text.