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US 2001/0012901 A1Published application
Sulphonyl compounds for use as linkers in solid phase and combinatorial synthesis
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsAkito Tanaka, Hideo Tsutsumi
Life of this patent
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Abstract
The present invention relates to a linker shown by the following formula (I): X—S02—R1—(A)m—R2 (I) wherein R1 is a group of the formula (A): 1 [wherein R3, R4 and R5 are the same or different hydrogen, etc], etc, R2 is a group which can form a chemical bond to a resin which may be protected by a conventional protective group, A is lower alkylene, etc, X is a leaving group, and m is an integer of 0 or 1, with proviso that A is (C2-C6)alkylene, and m is an integer of 1, when R1 is a group of the formula (A).
Claims14
A linker of the following formula (I):
- X—SO2—R1—(A)m—R2 (I)
- wherein
- R1 is a group of the formula (A), (B), (C), (D) and (E):
- 18
- [wherein
- R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 and R18 are the same or different hydrogen, lower alkyl or lower alkoxy, and
- n is an integer of 1 to 3],
- R2 is a group which can form a chemical bond to a resin which may be protected by a conventional protective group,
- A is lower alkylene or a group of the formula:
- —A1—O—A2—
- (wherein A1 and A2 are each lower alkylene),
- X is a leaving group, and
- m is an integer of 0 or 1,
- with proviso that A is (C2-C6)alkylene, and
- m is an integer of 1,
- when R1 is a group of the formula (A),
- or a salt thereof.
14 more elements
Dependencies are inferred from the claim text.