Method and preparing chiral esters
AssigneeSamsung Fine Chemicals Co., Ltd.
InventorsJai Wook Park, Mahn-Joo Kim, Jeong Hwan Koh, Hyun Min Jung
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Abstract
The present invention relates to a method for preparing a chiral ester and more particularly, the method for preparing an optically pure chiral ester from an alkenyl ester at a high yield by mixing and reacting: an alkenyl ester; a ruthenium complex to activate reduction reaction of said alkenyl ester and racemization; a lipase to acylate selectively one of enantiomers of said alkenyl ester; and a reducing agent to supply a hydride to said ruthenium complex. Said optically pure chiral ester of the present invention can be prepared by one-step synthesis from various types of alkenyl esters at a high yield.
Claims7
A process for preparing a chiral ester expressed in formula 100 by mixing and reacting:
- an alkenyl ester expressed by formula 6;
- a ruthenium complex selected from the group consisting of compounds 1 and 2 expressed in formulas 1 and 2 to activate reduction reaction of said alkenyl ester and racemization;
- a lipase to acylate selectively one of enantiomers of said alkenyl ester;
- and
- a reducing agent to supply a hydride to said ruthenium complex, 11
- wherein Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Y9, Y10, Y11, and Y12 are a hydrogen atom or C1-C2 alkyl group;
- X is Br, Cl or I;
- and Q is H, Br, Cl, or I. 12
- wherein Ph is phenyl. 13
- wherein R1, R2 and R3 are, independently, optionally substituted alkyl, optionally substituted aryl or optionally substituted cycloalkyl group and R1 and R2, R1 and R3, and R2 and R3 can be cyclized each other, where said substituent of alkyl, aryl and cycloalkyl is a halogen atom or a cyano group.
Dependencies are inferred from the claim text.