Substituted thiopyridines
AssigneeBASF SE
InventorsGerhard Hamprecht, Joachim Gebhardt, Heinz Isak, Michael Rack, Joachim Rheinheimer, Peter Schafer
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Abstract
Substituted thiopyridines of the general formula I 1 where n is 1 or 2; R1 is chlorine, C1-C3-fluoroalkyl, nitro or methylsulfonyl; R2 is a C1-C10-alkyl, C2-C10-alkenyl or C2-C10-alkynyl radical, in each case unsubstituted or substituted by halogen, C1-C4-alkoxy, C1-C4-alkoxycarbonyl, di-(C1-C4-alkylamino)carbonyl, cyano or nitro, a C3-C8-cycloalkyl radical, or a C1-C4-alkylenephenyl, phenyl or naphthyl radical which is unsubstituted or substituted in the phenyl moiety by halogen, C1-C3-alkyl, C1-C3-alkoxy, trifluoromethyl, cyano or nitro.
Claims7
A substituted thiopyridine of the general formula I 22
- where
- n is 1 or 2;
- R1 is chlorine, trifluoromethyl or difluoromethyl;
- R2 is a C1-C8-alkyl radical which is unsubstituted or substituted by chlorine or methoxy, or a benzyl or phenyl radical which is unsubstituted or substituted in the phenyl moiety by chlorine, methyl, methoxy or trifluoromethyl,
- with the exception of the compound:
- 3,5-dichloro-2-methylsulfinylpyridine.
A process as claimed in either of claims 3 and 4, wherein the oxidation of the pyridine thioethers Ia to give the thiopyridines I is effected with the aid of hydrogen peroxide in a mixture of acetic acid and trifluoroacetic acid in a ratio of 6:1 to 4:1 by volume.
A pyridine thioether of the general formula Ia 28
- where
- R1 is chlorine, trifluoromethyl or difluoromethyl;
- R2 is a C1-C8-alkyl radical which is unsubstituted or substituted by chlorine or methoxy, or a benzyl or phenyl radical which is unsubstituted or substituted in the phenyl moiety by chlorine, methyl, methoxy or trifluoromethyl,
- with the exception of the compounds:
- 2-(2-methyl-4-methoxyphenylthio)-3-chloro-5-trifluoromethylpyridine and 2-(3-methyl-4-methoxyphenylthio)-3-chloro-5-trifluoromethylpyridine.
Dependencies are inferred from the claim text.