Method of enhancing the effectiveness of dck phosphorylated molecules
AssigneeDana-Farber Cancer Institute, Inc.
InventorsHOWARD A FINE, DONALD W. KUFE, YOSHINOBU MANOME
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Abstract
A method of increasing the effectiveness of molecules that can be phosphorylated by dCK is described. This method involves transducing cells with the gene for deoxycytidine kinase which can chemosensitize the cell to molecules that are phosphorylated by dCK.
Claims10
A method for enhancing the effectiveness of molecules that are capable of being phosphorylated by deoxycytidine kinase (dCK) which comprises transducing a target cell with an effective amount of a nucleic acid sequence encoding a dCK protein having phosphorylation activity operably linked to a promoter, wherein said effective amount is the amount necessary to express the dCK protein that will phosphorylate said molecules.
Dependencies are inferred from the claim text.